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Articles 1 - 7 of 7
Full-Text Articles in Toxicology
Investigating The Effects Of 17Α-Ethynylestradiol On Mitochondrial Genome Stability, Alicia M. Chivers
Investigating The Effects Of 17Α-Ethynylestradiol On Mitochondrial Genome Stability, Alicia M. Chivers
Dissertations and Theses
Environmental toxicants are ubiquitous throughout the environment as a result of human activity. Among these toxicants, environmental estrogens are a category of particular concern due to their environmental prevalence and potency in altering reproductive traits. While many studies have addressed the detrimental effects of environmental estrogens on both aquatic and terrestrial organisms, few have analyzed the potential for these compounds to alter mitochondrial function. Mitochondria are the primary energy-generating system for all eukaryotic life, supporting all aspects of development, metabolism, and growth. Each cell within the body contains many mitochondria which in turn contain multiple copies of their own DNA …
Effect Of Bisphenol-A On Neurodevelopment In Drosophila Melanogaster Larvae, Alexandra M. Streifel
Effect Of Bisphenol-A On Neurodevelopment In Drosophila Melanogaster Larvae, Alexandra M. Streifel
All College Thesis Program, 2016-2019
This paper examines the effects of the chemical preservative bisphenol-A on the developing nervous systems of Drosophila melanogaster, or fruit fly, larvae. This study examines the effects of bisphenol-A using both behavioral as well as morphological paradigms. It was determined that bisphenol-A significantly increased the amount of time larvae spent in seeking behavior, the number of peristaltic contractions, and the distance traveled in a linear fashion. In the morphological analysis, indications of increased dendritic area in experimental larvae existed, but there was not enough data to determine significance. For future research, it is recommended that more data be gathered to …
Development Of A Dreissena Bioassay To Assess The Toxicity Of Contaminants Across Two Life-History Stages, Caroline Joyce Addis
Development Of A Dreissena Bioassay To Assess The Toxicity Of Contaminants Across Two Life-History Stages, Caroline Joyce Addis
Wayne State University Theses
Dreissenid mussels (Dreissena polymorpha and D. bugensis) have rapidly become widespread and ubiquitous in North America since their introduction into the Great Lakes in the 1980s. The resulting environmental and economic impacts of their invasion have been extensive, negatively affecting biodiversity and costing millions of dollars in control efforts and damage to power generation and water treatment facilities. Although dreissenids are often associated with negative impacts, they may present a practical tool for toxicology studies. The typically sessile behavior of the benthic adults coupled with the planktonic nature of the veligers allow for a more complete evaluation of water quality …
The Influence Of Abiotic Factors On The Uptake And Elimination Of 3-Trifluoromethyl-4-Nitrophenol By Larval Sea Lamprey (Petromyzon Marinus), Benjamin Livingston Hlina
The Influence Of Abiotic Factors On The Uptake And Elimination Of 3-Trifluoromethyl-4-Nitrophenol By Larval Sea Lamprey (Petromyzon Marinus), Benjamin Livingston Hlina
Theses and Dissertations (Comprehensive)
The backbone of sea lamprey (Petromyzon marinus) control in the Great Lakes is the use of the piscicide, 3-trifluoromethyl-4-nitrophenol (TFM), which is applied to streams containing larval sea lampreys. However, TFM effectiveness can be influenced by abiotic factors such as pH and temperature, which fluctuate daily and seasonally. The objectives of this thesis were to evaluate the influence of pH, temperature, and season on the toxicity, uptake, and elimination of TFM by larval sea lamprey. Radio-labeled TFM (14C-TFM) was used to determine how TFM uptake rates varied at different water pHs or temperatures during exposure to …
Nickel And Copper Mixture Toxicity To Daphnia In Soft Water, Prachi Deshpande
Nickel And Copper Mixture Toxicity To Daphnia In Soft Water, Prachi Deshpande
Theses and Dissertations (Comprehensive)
Industrially important metals, such as Cu and Ni, sometimes are present at elevated concentrations in lakes, including those in the Sudbury, ON region. Although they are essential metals, their divalent-cation state (Cu2+ and Ni2+) can be toxic at high concentrations in the water. The free-ion toxicity of each of these metals has been studied in isolation, but rarely as a mixture. The economic importance of Cu2+ and Ni2+ makes them essential to study in the context of mixture toxicity. The objectives were to: (1) determine Cu and Ni mixture toxicity to Daphnia through acute LC50 …
The Sublethal Physiological Effects Of Exposure To Copper And Silver Mixtures On Rainbow Trout (Oncorhynchus Mykiss), Wesley Truong
The Sublethal Physiological Effects Of Exposure To Copper And Silver Mixtures On Rainbow Trout (Oncorhynchus Mykiss), Wesley Truong
Theses and Dissertations (Comprehensive)
The mechanisms behind metal-metal interactions in freshwater environments are currently not well understood. Freshwater environments consist of many different types of metals, from those naturally present such as copper (Cu) and those that originate from anthropogenic sources like silver (Ag). Both Cu and Ag use apical sodium (Na+) channels for uptake into the gills of freshwater fish. In the gills, the mechanisms of Cu2+ and Ag+ toxicity appear to be similar to one another, which is by inhibiting Na+ /potassium (K+)- adenosine triphosphatase (NKA) and carbonic anhydrase (CA). Inhibition of NKA and CA …
Do Toxicity Modifying Factors Influence Acute Or Chronic Toxicity Of Thulium To Hyalella Azteca?, Alexandria H. Loveridge
Do Toxicity Modifying Factors Influence Acute Or Chronic Toxicity Of Thulium To Hyalella Azteca?, Alexandria H. Loveridge
Theses and Dissertations (Comprehensive)
The industrial demand for rare earth elements (REEs) is growing and as a result, environmental exposure is a concern. Very little is understood about the toxicity of REEs in aquatic environments. The objective of this research is to evaluate the acute and chronic toxicity of Tm and to also understand the toxicity modifying influence of dissolved organic matter (DOM) and cationic competition (Ca2+, Mg2+ and Na+). Furthermore, the aim of this study was to determine linkages between Tm bioaccumulation, growth and survival during chronic exposures. Standard methods (Environment Canada) were followed for both 96h acute and 14d chronic tests, in …