Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Animals (1)
- Benthos (1)
- Biomarker (1)
- Biotransformation (1)
- Blood-Brain Barrier (1)
-
- Blood-brain barrier (1)
- Brain (1)
- Calcium (1)
- Calcium Channel Blockers (1)
- Calcium Channels (1)
- Capillaries (1)
- Cattle (1)
- Cell Separation (1)
- Comet assay (1)
- Endothelial Cells (1)
- In Vitro Techniques (1)
- Influx (1)
- Male (1)
- Manganese (1)
- Metals (1)
- Polycyclic aromatic hydrocarbons (1)
- Proteins (1)
- Rats (1)
- Rats, Sprague-Dawley (1)
- Sodium (1)
- Sprague-Dawley (1)
- Store-operated calcium channel (1)
- Subcellular distribution (1)
- Temperature (1)
Articles 1 - 2 of 2
Full-Text Articles in Toxicology
Differences In Pah Tolerance Between Capitella Species: Underlying Biochemical Mechanisms, Lis Bach, Annemette Palmqvist, Lene Juel Rasmussen, Valery E. Forbes
Differences In Pah Tolerance Between Capitella Species: Underlying Biochemical Mechanisms, Lis Bach, Annemette Palmqvist, Lene Juel Rasmussen, Valery E. Forbes
Valery Forbes Publications
The polychaete Capitella capitata consists of a species complex within which differences in tolerance to toxicants have been observed. For example, it has been shown that Capitella sp. S is more sensitive (e.g., in terms of survival, growth and reproduction) to PAH and other stressors than the more opportunistic Capitella sp. I, which is able to take up and biotransform the PAH fluoranthene (Flu). In the present study, an investigation was performed to examine whether differences in tolerance between Capitella species sp. I and sp. S are due to differences in biotransformation, measured as the amount of Flu-metabolites produced by …
Manganese Distribution Across The Blood-Brain Barrier. Iv. Evidence For Brain Influx Through Store-Operated Calcium Channels, Janelle S. Crossgrove, Robert A. Yokel
Manganese Distribution Across The Blood-Brain Barrier. Iv. Evidence For Brain Influx Through Store-Operated Calcium Channels, Janelle S. Crossgrove, Robert A. Yokel
Pharmaceutical Sciences Faculty Publications
Manganese (Mn) is a required co-factor for many ubiquitous enzymes; however, chronic Mn overexposure can cause manganism, a parkinsonian-like syndrome. Previous studies showed Mn influx into brain is carrier-mediated, though the putative carrier(s) were not established. Studies conducted with cultured bovine brain microvascular endothelial cells (bBMECs), which comprise the blood–brain barrier, revealed 54Mn (II) uptake positively correlated with pH, was temperature-dependent, and was sodium- and energy-independent. Brain 54Mn uptake correlated inversely with calcium (Ca) concentration, but 45Ca uptake was unaltered by high Mn concentration. Lanthanum (La), a non-selective inhibitor of several Ca channel types, as well as …