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Full-Text Articles in Toxicology
Non-Cytotoxic Antibacterial Silver–Coumarin Complex Doped Sol–Gel Coatings, Swarna Jaiswal, Kunal Bhattacharya, Maeve Sullivan, Maureen Walsh, Bernadette Creaven, Fathima Laffir, Brendan Duffy, Patrick Mchale
Non-Cytotoxic Antibacterial Silver–Coumarin Complex Doped Sol–Gel Coatings, Swarna Jaiswal, Kunal Bhattacharya, Maeve Sullivan, Maureen Walsh, Bernadette Creaven, Fathima Laffir, Brendan Duffy, Patrick Mchale
Articles
Microbial colonisation on clinical and industrial surfaces is currently of global concern and silane based sol–gel coatings are being proposed as potential solutions. Sol–gels are chemically inert, stable and homogeneous and can be designed to act as a reservoir for releasing antimicrobial agents over extended time periods. In the present study, silver nitrate (AgN) and a series of silver coumarin complexes based on coumarin-3-carboxylatosilver (AgC) and it is 6,7 and 8 hydroxylated analogues (Ag6, Ag7, Ag8) were incorporated into sol–gel coatings. The comparative antibacterial activity of the coatings was determined against meticillin resistant Staphylococcus aureus (MRSA) and multidrug resistance Enterobacter …