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Full-Text Articles in Toxicology
Verapamil Inhibits The Glucose Transport Activity Of Glut1, Larry L. Louters, Nathan Stehouwer, Janelle Rekman, Andrew Tidball
Verapamil Inhibits The Glucose Transport Activity Of Glut1, Larry L. Louters, Nathan Stehouwer, Janelle Rekman, Andrew Tidball
University Faculty Publications and Creative Works
Calcium channel blocker toxicity has been associated with marked hyperglycemia responsive only to high-dose insulin therapy. The exact mechanism(s) of this induced hyperglycemia has not been clearly delineated. The glucose transporter GLUT1 is expressed in a wide variety of cell types and is largely responsible for a basal level of glucose transport. GLUT1 also is activated by cell stress. The specific purpose of this study was to investigate the effects of the calcium channel blocker verapamil on the glucose uptake activity of GLUT1 in L929 fibroblasts cells. Dose-dependent effects of verapamil on glucose uptake were studied using L929 fibroblast cells …
Verapamil Inhibits The Glucose Transport Activity Of Glut1, Larry L. Louters, Nathan Stehouwer, Janelle Rekman, Andrew Tidball
Verapamil Inhibits The Glucose Transport Activity Of Glut1, Larry L. Louters, Nathan Stehouwer, Janelle Rekman, Andrew Tidball
University Faculty Publications and Creative Works
Calcium channel blocker toxicity has been associated with marked hyperglycemia responsive only to high-dose insulin therapy. The exact mechanism(s) of this induced hyperglycemia has not been clearly delineated. The glucose transporter GLUT1 is expressed in a wide variety of cell types and is largely responsible for a basal level of glucose transport. GLUT1 also is activated by cell stress. The specific purpose of this study was to investigate the effects of the calcium channel blocker verapamil on the glucose uptake activity of GLUT1 in L929 fibroblasts cells. Dose-dependent effects of verapamil on glucose uptake were studied using L929 fibroblast cells …