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Full-Text Articles in Toxicology
Influence Of Lipophilicity On The Accumulation And Distribution Of Halogenated Phenols And A Pyridinol As Metabolites Of Pesticides In The Rat, Assed A. Attumi
Influence Of Lipophilicity On The Accumulation And Distribution Of Halogenated Phenols And A Pyridinol As Metabolites Of Pesticides In The Rat, Assed A. Attumi
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Exposure to halogenated phenols and pyridinols is of increasing concern because of their wide use and distribution. This research was initiated to determine the distribution, accumulation, and depletion of a group of halogenated phenols and a pyridinol in selected tissues of male weanling rats at different time intervals following a single oral dose of 0.33 or 1.66 m moles per kg body weight. The halogenated phenols and pyridinol were distributed differently in every tissue sampled following their administration, even though the amount administered was the same in each case. The concentrations in tissue were found in the order: 2,4,5-trichlorophenol > 4-bromo-2,5-dichlorophenol …
The Covalent Interaction Of Hepatic Metabolites Of The Insecticide Chlordane With Cellular Macromolecules In The Rat And Mouse In Vitro, Alan A. Brimfield
The Covalent Interaction Of Hepatic Metabolites Of The Insecticide Chlordane With Cellular Macromolecules In The Rat And Mouse In Vitro, Alan A. Brimfield
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
This investigation addressed several aspects of the covalent interaction of metabolites of the insecticide chlordane with cellular macromolecules in vitro. Microsomal preparations from the liver of mice and rats were used and covalent binding to microsomal protein and RNA or to added calf thymus DNA was studied. Pure 14C-labelled cis- and trans-chlordane isomers as well as an isomeric mixture (14C-cis-chlordane plus 14C-trans-chlordane 3:1, w:w) were used as substrates for the in vitro system. Biochemical parameters investigated included inhibition of microsomal mixed-function oxidase and epoxide hydratase plus the induction of these enzymes by pretreatment with chlordane …