Toxicology Commons^™

Inhibition Of Synaptosomal Biogenic Amine Transport By A Diverse Group Of Neurotoxic Chemicals, William M. Bracken

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Synaptosomal membrane functions were monitored, after in vitro exposure to select environmental pollutants, in synaptosomal preparations originating from rat cerebral cortices. The uptake of NE and 5HT into the synaptosomes was monitored as was the K⁺-dependent phosphate activity of the membrane. CH₃HgCl, Hg(NO₃)₂, CdCl₂, diisopropylfluorophosphate (DFP), paraoxon, acrylamide and Kepone were the test chemicals whose effects were studied.

CH₃HgCl, Hg(NO₃)₂ and Kepone had the greatest inhibitory effects on NE and 5HT uptake. The concentrations producing 50 percent inhibition (IC₅₀) were 1.4 x 10 …