Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- 2 (1)
- 3 (1)
- 7 (1)
- 8-Tetrachlorodibenzo-P-Dioxin TCDD (1)
- AH receptor (1)
-
- Brominated flame-retardants (1)
- Competitive interactions (1)
- Culture (1)
- Density functional theory (1)
- Dibenzo-para-dioxins (1)
- Dinoflagellates (1)
- Endocrine disrupting compounds (1)
- Exposure (1)
- Functional type (1)
- Halogen bonding (1)
- In vitro (1)
- Mechanisms (1)
- Molecular orbital theory (1)
- Polybrominated diphenyl ethers (1)
- Standardized fish bioassay (1)
- Thyroid hormone system (1)
- Thyroid hormones (1)
- Toxic Pfiesteria complex (1)
Articles 1 - 2 of 2
Full-Text Articles in Toxicology
Halogen Bonding Interactions Of Haloaromatic Endocrine Disruptors And The Potential For Inhibition Of Iodothyronine Deiodinases, Craig A. Bayse
Halogen Bonding Interactions Of Haloaromatic Endocrine Disruptors And The Potential For Inhibition Of Iodothyronine Deiodinases, Craig A. Bayse
Chemistry & Biochemistry Faculty Publications
Halogen bonding (XB) is a potential mechanism for the inhibition of the thyroid-activating/deactivating iodothyronine deiodinase family of selenoproteins through interactions with halogenated endocrine disrupting compounds (EDCs). Trends in XB interactions were examined using density functional theory for a series of polyhalogenated dibenzo-1,4-dioxins, biphenyls, and other EDCs with methylselenolate, a simple model of the Dio active site selenocysteine. The strengths of the interactions depend upon the halogen (Br>Cl), the degree of substitution, and the position of the acceptor. In terms of donor-acceptor energies, interactions at the meta position are often the strongest, suggesting a link to the topology of THs, …
The Standardized Fish Bioassay Procedure For Detecting And Culturing Actively Toxic Pfiesteria, Used By Two Reference Laboratories For Atlantic And Gulf Coast States, Joann M. Burkholder, Harold G. Marshall, David W. Seaborn, Nora J. Deamer-Melia
The Standardized Fish Bioassay Procedure For Detecting And Culturing Actively Toxic Pfiesteria, Used By Two Reference Laboratories For Atlantic And Gulf Coast States, Joann M. Burkholder, Harold G. Marshall, David W. Seaborn, Nora J. Deamer-Melia
Biological Sciences Faculty Publications
In the absence of purified standards of toxins from Pfiesteria species, appropriately conducted fish bioassays are the "gold standard" that must be used to detect toxic strains of Pfiesteria slop. from natural estuarine water or sediment samples and to culture actively toxic Pfiesteria. In this article, we describe the standardized steps of our fish bioassay as an abbreviated term for a procedure that includes two sets of trials with fish, following the Henle-Koch postulates modified for toxic rather than infectious agents. This procedure was developed in 1991, and has been refined over more than 12 years of experience in …