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Synthesis Of 6-Aminopenicillanic Acid-Protein Conjugates For Development Of Enzyme Immunoassay For B-Lactam Antibiotics, Alice Ann Heth
Synthesis Of 6-Aminopenicillanic Acid-Protein Conjugates For Development Of Enzyme Immunoassay For B-Lactam Antibiotics, Alice Ann Heth
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
An enzyme immunoassay specific for several β-lactam antibiotics rather than individual antibiotics was investigated. The goal to develop an enzyme immunoassay for analysis of a whole class of compounds at one time is different than the goal of most enzyme immunoassays which desire specificity for drugs or hormone levels. Detection of the presence of all β-lactam antibiotics is wanted and identification of specific antibiotics is not needed.
6-Aminopenicillanic acid, the common structural moiety of β-lactam antibiotics was used tin this investigation. Methods of preparation of 6-aminopencillanic acid conjugates and antibodies needed for enzyme immunoassays have been developed. 6-Aminopenicillanic acid was …