Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Animal Experimentation and Research (1)
- Behavioral Neurobiology (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
-
- Cellular and Molecular Physiology (1)
- Medicine and Health Sciences (1)
- Molecular Biology (1)
- Molecular and Cellular Neuroscience (1)
- Natural Products Chemistry and Pharmacognosy (1)
- Neuroscience and Neurobiology (1)
- Pharmacy and Pharmaceutical Sciences (1)
- Physiology (1)
- Research Methods in Life Sciences (1)
- Keyword
-
- AGE (1)
- Addiction (1)
- Advanced Glycation End-Products (1)
- Aging (1)
- Behavior (1)
-
- Cannabidiol (1)
- Cannabinoids (1)
- Cannabis (1)
- Cardiac Fibroblasts (1)
- Development (1)
- Diabetes (1)
- EPAC (1)
- Embryogenesis (1)
- Estrane (1)
- Hormones (1)
- Locomotion (1)
- Neuroprotection (1)
- Oxidative Stress (1)
- P-NF-kB (1)
- Pregnane (1)
- RAGE (1)
- Rap1a (1)
- Receptor for Advanced Glycation End-Products (1)
- Rodent (1)
- Sex steriods (1)
- Superoxide Dismutase (1)
- Tetrahydrocannabinol (1)
- Withdrawal (1)
- Zebrafish (1)
- Publication Type
Articles 1 - 8 of 8
Full-Text Articles in Pharmacology
Hiv-1 Tat Interactions With Opioids Are Modulated By Progesterone And Estradiol, Dejun Jackson
Hiv-1 Tat Interactions With Opioids Are Modulated By Progesterone And Estradiol, Dejun Jackson
Honors Theses
HIV infection and combined substance abuse are comorbid epidemics. Previous studies show that concurrent opioid drug use may potentiate HIV-1-mediated neurotoxicity partly via interactions with opioids. Preclinical studies suggest that the HIV-1 trans-activator of transcription (Tat), an HIV regulatory protein, can synergize with opioids to exacerbate its already neurotoxic effects. However, its interactions with clinical opioids, such as oxycodone, have yet to be elucidated. Additionally, Tat disrupts a number of systems including the dopaminergic system, which contribute to its capacity to potentiate the rewarding effects of abused drugs. Although the neurotoxic effects of Tat may be inhibited by gonadal steroids …
The Impact Of Age/Rage Signaling On Oxidative Stress Under Diabetic Conditions In Cardiac Fibroblasts, Christopher Dorroh
The Impact Of Age/Rage Signaling On Oxidative Stress Under Diabetic Conditions In Cardiac Fibroblasts, Christopher Dorroh
Honors Theses
Diabetes is a major health concern in the United States, with 1.5 million new cases diagnosed each year. Patients who suffer from diabetes have an increased risk of developing heart failure, a form of cardiovascular disease. Heart failure has been shown to result from increased left ventricular stiffness, which in turn is caused by increased remodeling of the extracellular matrix (ECM). This increase in ECM remodeling is a result of AGE/RAGE signaling, which occurs at a heightened level in the cardiac fibroblast cells of diabetics. Studies have shown that diabetics have elevated levels of AGEs (Advanced Glycation End-Products), which bind …
Impacts Of Embryonic Exposure To Cannabidiol Or ∆9-Tetrahydrocannabinol On Zebrafish (Danio Rerio) Frailty In F0 And F1 Generations, Anika Faruque
Impacts Of Embryonic Exposure To Cannabidiol Or ∆9-Tetrahydrocannabinol On Zebrafish (Danio Rerio) Frailty In F0 And F1 Generations, Anika Faruque
Honors Theses
Exposure to cannabinoids during critical development periods has increased with epileptic children being commonly prescribed CBD for seizures and pregnant women taking it recreationally. Many studies have been done on the possible benefits and drawbacks of cannabinoid exposure on the human brain, but not much is known about how it can affect the developing brain long-term. To see the potential adverse effects of cannabinoid exposure during critical stages of development and discover potential developmental origins of disease in consuming cannabinoids during embryogenesis, zebrafish embryos (6-96 hours post fertilization) were exposed to varying concentrations of CBD (0.02, 0.1, 0.5 µM), THC …
Development Of Inhalable Nano-Lipid Carriers For The Treatment Of Pulmonary Aspergillosis Using Hot Melt Extrusion Technology, Gauri Shadambikar
Development Of Inhalable Nano-Lipid Carriers For The Treatment Of Pulmonary Aspergillosis Using Hot Melt Extrusion Technology, Gauri Shadambikar
Graduate Student Council Research Grants
Overview: I am Gauri Shadambikar, second year PhD. student in department of Pharmaceutics and Drug Delivery. Pulmonary Aspergillosis is an infection caused by a type of mold and can have serious effects on patients with a weak immune system or with underlying lung disease1. Itraconazole, a triazole is a compound with a broad antifungal spectrum. 2. An inhalation-based drug delivery system has the advantage of rapid onset of action directly at the site of infection along with controlled and prolonged delivery. 3. Hence the aim of my project was to prepare inhalable nano-lipid carriers (NLC) which would be a viable …
Assessment Of Underlying Neurocircuitry In Dysregulation Of The Hypothalamic Pituitary Adrenal Stress Axis In Hiv-1 Tat Male Mice, Salahuddin Mohammed
Assessment Of Underlying Neurocircuitry In Dysregulation Of The Hypothalamic Pituitary Adrenal Stress Axis In Hiv-1 Tat Male Mice, Salahuddin Mohammed
Graduate Student Council Research Grants
Overview: My name is Salahuddin Mohammed, a 2nd year PhD graduate student from Dr. Jason Paris’ Lab. My research dissertation focuses on investigating the neuroendocrine underpinnings of HIV-and opioid-mediated anxiety-/depression-like behavior and cognitive impairment via experiments utilizing humans and animal models. Through this work I strive to delineate the underlying mechanism for the neuroHIV symptomology and develop novel therapeutic agents which can ameliorate HIV-1 mediated Tat-neurotoxicity. Approximately 50% of the HIV infected patients suffer from HIV associated neurocognitive disorders (HAND) which can be exacerbated by drug use/abuse. Some neuroHIV symptoms include anxiety, major depressive disorder, neurocognitive impairment, and additional psychiatric …
Development Of Itraconazole Topical Formulation In Skin Cancer Treatment, Praveen Kolimi
Development Of Itraconazole Topical Formulation In Skin Cancer Treatment, Praveen Kolimi
Graduate Student Council Research Grants
Overview: I, Praveen Kolimi, pursuing a first-year graduate program at the department of pharmaceutics and drug delivery. This Graduate Student Council (GSC) grant proposal focus on topical application of Itraconazole (ICZ) in skin cancer treatment.
Intellectual Merit: 5.4 million skin cancer cases are reported each year in the United States. A study disclosed that one among five Americans are likely to develop skin cancer in their entire life. 9. Skin cancer can be distinguished into two types, malignant melanoma (MM) and non-melanoma skin cancer (NMSC) 1, 8. NMSC further classified into squamous cell carcinoma (SCC) and basal cell carcinoma (BCC)8, …
The Role Of Insulin-Like Growth Factor 1 In Specific Brain Cells Following Ischemia, Cellas Hayes
The Role Of Insulin-Like Growth Factor 1 In Specific Brain Cells Following Ischemia, Cellas Hayes
Graduate Student Council Research Grants
Overview: My name is Cellas Ari’ka Hayes, and I am a first-year graduate student in the School of Pharmacy Department of BioMolecular Sciences. I am pursuing a Ph.D. in Pharmaceutical Sciences with an emphasis in Pharmacology. My project will assess the effects of insulin-like growth factor-1(IGF-1), an anabolic polypeptide on the damage caused by ischemic stroke including glial cell death, neuronal tress, infarct size, neurological deficits, and behavioral changes.
Intellectual Merit: Ischemia is one of the largest causes of neurological deficits that in elderly individuals in the United States [1]. Since our life expectancy has increased concurrently without predispositions to …
Α-Tocopherol Succinate Nanostructured Lipid Carriers For The Ocular Delivery Of The Anti-Neoplastic Agent, Sushrut Marathe
Α-Tocopherol Succinate Nanostructured Lipid Carriers For The Ocular Delivery Of The Anti-Neoplastic Agent, Sushrut Marathe
Graduate Student Council Research Grants
Overview: Retinoblastoma (RB) is a rare form of cancer that rapidly develops from the immature cells of the retina, the light-detecting tissue of the eye. The treatment options of RB has been limited to enucleation, external beam radiotherapy, episcleral plaque radiotherapy and cryotherapy. α-Tocopherol succinate(αTS), has been proven to an effective apoptogenic agent. It can enhance the efficiency of the anticancer agent1. Paclitaxel (Ptx) is a potent chemo agent and is widely used in the treatment of various types of cancers. However, clinical use of Paclitaxelis limited by systemic toxicity, rapid clearance and resistance 2,3.The formulation of paclitaxel poses the …