Pharmacology Commons^™

Wastewater-Informed Public Health Intervention Playbook

Sustain Magazine

As the SARS-CoV-2 pandemic quickly spread from country to country and continent to continent in 2020, governments and scientists needed a way to track COVID-19 through populations in order to position public health interventions in the most impactful locations. Having a decision-based risk framework may help to guide policy creation that could minimize or prevent possible outbreaks and surges of infection within communities. The University of Louisville in partnership with Louisville’s Department of Public Health and Wellness tested this strategy in 2021 and 2022. This Wastewater-Informed Public Health Intervention Playbook describes the decisions and actions of that academic and public …

Cannabinoids And Retinal Fibrotic Disorders., Lucy June Sloan

Electronic Theses and Dissertations

Retinal fibrosis is detrimental to vision. Retinal pigment epithelial (RPE) cells contribute to several retinal fibrotic diseases. Upon exposure to TGF-β, a key fibrotic cytokine, RPE cells trans-differentiate to myofibroblasts marked by the integration of α-SMA fibers into F-actin stress fibers, which confer strong contractility. Myofibroblasts produce and contract the collagen-rich fibrotic scar and disrupt retinal architecture. In this study, we investigated the in vitro effects of the putative endocannabinoid compound N-oleoyl dopamine (OLDA) on TGF-β2 induced porcine RPE cell contraction and α-SMA expression. Using an in vitro collagen matrix contraction assay, we found that OLDA inhibited TGF-β2 induced contraction …

Implementation Of A Drive-Through Covid-19 Mass Vaccination Site: Experiences From Louvax–Broadbent In Louisville, Kentucky, Ruth Carrico, Sarah Beth Hartlage, Valenchia Brown Msn, Aprn, Fnp-C, Sarah M. Bishop, Luanne Didelot, William Hayden, Beverly Williams Coleman, Sarah Tan, Delanor Manson, Kellie Kane, Dawn Balcom, Paul Kern

The University of Louisville Journal of Respiratory Infections

Background: Response to the COVID-19 pandemic has required innovative approaches to vaccination, including methods to rapidly and safely immunize communities. A major challenge to such a response involved access to untapped healthcare worker resources. The Louisville, Kentucky, response involved the use of a large volunteer workforce to supplement local public health employees in planning and implementing a large-scale drive-through vaccination event. The objective of this manuscript was to outline processes involved in training a mass immunization workforce and implementating a large-scale COVID-19 community vaccination.

Approach: Competency-based and standardized training was provided for every volunteer before working their shift. Volunteers worked …

N-Acetyltranserase 2 (Nat2) Genotype Polymorphism In Cryopreserved Human Hepatocytes And Chinese Hamster Ovary (Cho) Cells., Mariam Refaat Zaky Habil

Electronic Theses and Dissertations

Arylamine N-acetyltransferases, NAT1 and NAT2, catalyze the detoxification and/or activation of drugs and aromatic amine carcinogens. Single nucleotide polymorphisms or SNPs result in different human NAT2 genotypes thus dividing the population into rapid, intermediate, and slow acetylators. We hypothesize allelic variants of NAT2 genotype will decrease levels of N-acetylation, cytotoxicity, oxidative stress, DNA adduct formation, and mutagenesis compared to the reference allele NAT2*4. Cryopreserved human hepatocytes expressing different NAT2 genotypes and NER-deficient Chinese hamster ovary (CHO) cells transfected with human CYP1A2 and human NAT2*4, NAT2*5B or NAT2*7B have been used to investigate N-acetylation of different xenobiotics. In …

Sustainable Solutions, Fall/Winter 2020, Issue 41

Sustain Magazine

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Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22

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Sustainable Communities, Fall/Winter 2010, Issue 21

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Sustainable Building, Spring/Summer 2009, Issue 20

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Environmental History, Fall/Winter 2009, Issue 19

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Student Research, Spring/Summer 2008, Issue 18

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Evolving Pollution Prevention, Fall/Winter 2008, Issue 17

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Climate Change, Spring/Summer 2007, Issue 16

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Our Energy Future, Fall/Winter 2007, Issue 15

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Land Conservation, Spring/Summer 2006, Issue 14

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Pollution And Heart Disease, Fall/Winter 2006, Issue 13

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Green Cities, Spring/Summer 2005, Issue 12

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Global Sustainability, Fall/Winter 2005, Issue 11

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Environmental Justice, Spring/Summer 2004, Issue 10

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Kentucky's Environmental Future, Fall/Winter 2004, Issue 9

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Urban Ecology, Spring/Summer 2003, Issue 8

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Urban Regeneration, Fall/Winter 2003, Issue 7

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Urban Air Quality, Spring/Summer 2002, Issue 6

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Sustainability Of Industrialized Agriculture, Fall/Winter 2002, Issue 5

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Urban Design For Environmental Protection, Spring/Summer 2001, Issue 4

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Stream Restoration, Spring/Summer 2011, Issue 24

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Renewable Energy, Fall/Winter 2011, Issue 23

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Biodiversity, Fall/Winter 2012, Issue 25

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Active Transportation, Spring/Summer 2012, Issue 26

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Heat Islands, Fall/Winter 2014, Issue 29

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Sustainable Behavior, Spring/Summer 2013, Issue 28

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