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Full-Text Articles in Pharmacology
The Inflammatory Response Initiated By The Spleen To Ischemic Stroke, Hilary Seifert
The Inflammatory Response Initiated By The Spleen To Ischemic Stroke, Hilary Seifert
USF Tampa Graduate Theses and Dissertations
The peripheral immune system plays a role in delayed neural injury after stroke. This response originates from the spleen as splenectomy prior to middle cerebral artery occlusion (MCAO) in rats significantly reduces infarct volume in the brain. This research is based on the hypothesis that inhibiting the splenic response will reduce neurodegeneration after stroke. Studies in animals have implicated lymphocytes as the immune cell type that is detrimental following MCAO. Interferon gamma (IFNγ) has been identified as a pro-inflammatory cytokine that is also detrimental following stroke. IFNγ is important because it activates microglia and macrophages in a pro-inflammatory nature that …
Cd44 Containing Complexes As A Therapeutic Target In Multiple Myeloma, Anthony Gebhard
Cd44 Containing Complexes As A Therapeutic Target In Multiple Myeloma, Anthony Gebhard
USF Tampa Graduate Theses and Dissertations
Our laboratory recently reported that treatment with the d-amino acid containing peptide HYD1 induces necrotic cell death in multiple myeloma (MM) cell lines. Due to the intriguing biological activity and promising in vivo activity of HYD1, we pursued strategies for increasing the therapeutic efficacy of the parent linear peptide. These efforts led to the development of a cyclized peptidomimetic, MTI-101, with increased in vitro activity and robust in vivo activity as a single agent using two myeloma models that consider the bone marrow microenvironment. MTI-101 treatment resulted in mechanistically similar hallmarks of HYD1 induced cell death, namely the generation of …