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Full-Text Articles in Pharmacology, Toxicology and Environmental Health

Modulatory Effects Of Citrus Flavonoids Towards The Metabolism And Mutagenicity Of Environmental Carcinogens, Wayne L. Bear Mar 2002

Modulatory Effects Of Citrus Flavonoids Towards The Metabolism And Mutagenicity Of Environmental Carcinogens, Wayne L. Bear

Loma Linda University Electronic Theses, Dissertations & Projects

The environmental carcinogens classified as heterocyclic amines (HCA’s) and the tobacco-specific nitrosamine NNK generally require internal enzymatic activation. This activation occurs via cytochrome P450 (CYP) enzymes and leads to metabolites that bind to human DNA which may in turn cause mutations which may then in turn lead to carcinogenesis. Certain nonnutritive plant compounds termed phytochemicals may protect against HCA and NNK-induced mutagenesis and carcinogenesis. We investigated the potential protective effects of five different phytochemicals of the flavonoid class which naturally occur in citrus. These flavonoids were diosmin, naringin. naringenin, rutin, and quercetin. Our results suggest that naringenin and quercetin were …


Functional Screening For The Effects Of New Acyl Aniline And Acyl Aminopyridine Derivatives On Calcium Entryin Rat Aortic Smooth Muscle(การทดสอบผลของสารสังเคราะห์ใหม่ในกลุ่มเอ..., Patummas Puechprom, Prasan Dhumma-Upakorn, Chamnan Patarapamch, Suree Jianmongkol Jan 2002

Functional Screening For The Effects Of New Acyl Aniline And Acyl Aminopyridine Derivatives On Calcium Entryin Rat Aortic Smooth Muscle(การทดสอบผลของสารสังเคราะห์ใหม่ในกลุ่มเอ..., Patummas Puechprom, Prasan Dhumma-Upakorn, Chamnan Patarapamch, Suree Jianmongkol

The Thai Journal of Pharmaceutical Sciences

Previously, CU 18-08, CU 18-10, acyl aniline derivatives, as well as CU 18-11, an acyl aminopyridine derivative, were shown to suppress the spontaneous contraction of rat duodenum. This study was to investigate the potential effects of these three synthe...


Risk Factors Of Antituberculosis Drugs-Induced Hepatotoxicity In Thai Patients(ปัจจัยเสี่ยงของการเกิดพิษต่อตับจากยาต้านวัณโรคในผู้ป่วยคนไ..., Sarinee Kiittiyanunt, Rungpetch Sakulbamrungsil, Supakit Wongwiwatthananukit, Wisan Suthiputthanangoon Jan 2002

Risk Factors Of Antituberculosis Drugs-Induced Hepatotoxicity In Thai Patients(ปัจจัยเสี่ยงของการเกิดพิษต่อตับจากยาต้านวัณโรคในผู้ป่วยคนไ..., Sarinee Kiittiyanunt, Rungpetch Sakulbamrungsil, Supakit Wongwiwatthananukit, Wisan Suthiputthanangoon

The Thai Journal of Pharmaceutical Sciences

The purpose of this retrospective-analytical research, unmatched case-control was to determine the rate and risk factors of hepatotoxicity in inpatients with tuberculosis at King Chulalongkorn Memorial Hospital. The patients who received three antituberc...


Antimicrobial Activities Of Medicinal Plant Products(ฤทธิ์ต้านจุลินทรีย์ของผลิตภัณฑ์สมุนไพร), Areerat Laorpaksa, Nongluksna Sriubolmas, Peerapun Khruddhaveacho Jan 2002

Antimicrobial Activities Of Medicinal Plant Products(ฤทธิ์ต้านจุลินทรีย์ของผลิตภัณฑ์สมุนไพร), Areerat Laorpaksa, Nongluksna Sriubolmas, Peerapun Khruddhaveacho

The Thai Journal of Pharmaceutical Sciences

This study determined antimicrobial activities of 57 selected medicinal plant products with antimicrobial indications by agar diffusion assay. The percentage of samples exhibiting antibacterial activities against Staphylococcus aureus ATCC 29213, Salmone...


Effect Of H2-Antagonists On Paracellular Drug Absorption(ผลของ H2-Antagonists ต่อการดูดซึมยาทาง Paracellular), Nusara Piyapolrungroj, Vichien Leelasangaluk Jan 2002

Effect Of H2-Antagonists On Paracellular Drug Absorption(ผลของ H2-Antagonists ต่อการดูดซึมยาทาง Paracellular), Nusara Piyapolrungroj, Vichien Leelasangaluk

The Thai Journal of Pharmaceutical Sciences

Purpose: The objective of this study was to investigate the effects of H2-antagonists on the absorption of co-administered drugs. Methods: Permeability across Caco-2 monolayers of various small drugs transported by transcellular or paracellular pathway w...


Effect Of Valproyl Morpholine On Rat Hepatic Cytochrome P450 : In Vivo And In Vitro Studies(ผลของวัลโปรอิล มอร์โฟลิน ต่อเอนไซม์ไซโตโครมพี 450 ในตับหนู..., Somsong Lawanprasert, Pornpimol Kijsanayotin, Nuansri Niwattisaiwong, Kanlayanee Yana, Mayuree Tantisira, Chamnan Patarapamch Jan 2002

Effect Of Valproyl Morpholine On Rat Hepatic Cytochrome P450 : In Vivo And In Vitro Studies(ผลของวัลโปรอิล มอร์โฟลิน ต่อเอนไซม์ไซโตโครมพี 450 ในตับหนู..., Somsong Lawanprasert, Pornpimol Kijsanayotin, Nuansri Niwattisaiwong, Kanlayanee Yana, Mayuree Tantisira, Chamnan Patarapamch

The Thai Journal of Pharmaceutical Sciences

Effect of valproyl morpholine (VPM) on rat hepatic cytochrome P450 (CYP) was investigated. Median effective anticonvulsant dose of VPM in mice (100 mg/kg/day) as well as of valproic acid (VPA, the prototype of VPM) (250 mg/kg/day) were given intraperiton...


Sufficiency And Consistency Of Drug In Formation On Drug Labels And Leaflets(ความพอเพียงและความคงที่ของข้อมูลยาบนฉลากและเอกสารกำกับยา), Siriporn Burapadaja, Busabong Jamroendararasamee, Jaratbhan Sanguansermsri Jan 2002

Sufficiency And Consistency Of Drug In Formation On Drug Labels And Leaflets(ความพอเพียงและความคงที่ของข้อมูลยาบนฉลากและเอกสารกำกับยา), Siriporn Burapadaja, Busabong Jamroendararasamee, Jaratbhan Sanguansermsri

The Thai Journal of Pharmaceutical Sciences

According to the official regulation, it was compulsory to provide w ritten drug inform ation on the drug labels and leaflets w ith the drug products. But the content of drug inform ation w as not totally specified by the regulation. Thus this study aime...


Screening Of Thai Medicinal Plants For Anti-Hepatitis B Virus Activity And Antimicrobial Activity(การตรวจกรองหาสมุนไพรไทยที่มีฤทธิ์ต้านไวรัสตับอักเสบบ..., Sattaporn Sirotamarat, Surattana Amnuoypol, Thaveechai Vachirayonstien, Thananchai Kitvivattanachai Jan 2002

Screening Of Thai Medicinal Plants For Anti-Hepatitis B Virus Activity And Antimicrobial Activity(การตรวจกรองหาสมุนไพรไทยที่มีฤทธิ์ต้านไวรัสตับอักเสบบ..., Sattaporn Sirotamarat, Surattana Amnuoypol, Thaveechai Vachirayonstien, Thananchai Kitvivattanachai

The Thai Journal of Pharmaceutical Sciences

Forty-six ethanol extracts of Thai medicinal plants were screened for anti—hepatitis B virus activity and antimicrobial activity by ELISA (Enzyme-linked immunosorbent assay) test and agar diffusion method , respectively. Inhibition of the HBsAg secreti...


Anti-Inflammatory And Bactericidal Properties Of Selected Indigenous Medicinal Plants Used For Dysuria(ฤทธิ์ต้านการอักเสบและฆ่าแบคทีเรียของพืชสมุนไพรท้อง..., Bungorn Sripanidkulchai, Unchalee Tattawasart, Pisamai Laupattarakasem, Varima Wongpanich Jan 2002

Anti-Inflammatory And Bactericidal Properties Of Selected Indigenous Medicinal Plants Used For Dysuria(ฤทธิ์ต้านการอักเสบและฆ่าแบคทีเรียของพืชสมุนไพรท้อง..., Bungorn Sripanidkulchai, Unchalee Tattawasart, Pisamai Laupattarakasem, Varima Wongpanich

The Thai Journal of Pharmaceutical Sciences

Aqueous extracts of five plants having ethnomédical application for dysuria were investigated for anti-inflammatory and bactericidal activity. The extracts of Ananas comosus and Carica papaya roots and of Averrhoa carambola stem inhibited rat paw inflam...


Determination Of Volatile Compounds From Hoy A Carnosa Flowers (Asclepiadaceae)(การวิเคราะห์หาสารประกอบที่ระเหยได้จากดอก Hoya Carnosa (Asclepiadaceae)), Jankana Burana-Osot, Gerhard Buchbauer Jan 2002

Determination Of Volatile Compounds From Hoy A Carnosa Flowers (Asclepiadaceae)(การวิเคราะห์หาสารประกอบที่ระเหยได้จากดอก Hoya Carnosa (Asclepiadaceae)), Jankana Burana-Osot, Gerhard Buchbauer

The Thai Journal of Pharmaceutical Sciences

The volatile components from Hoya carnosa (L. f.) R. Br. flowers (Asclepiadaceae) were determined by three extraction methods: hydrodistillation, headspace trapping and solid-phase microextraction. The extracts were analyzed and identified by GC-FID and ...


In Vitro Study Of The Combination Between P-Lactams And Aminoglycosides To Eradicate Escherichia Coli From Sepsis Patients(การใช้เบต้าแลคแตมร่วมกับอะมโนไกลโคไซด์เพื่อ..., Pisit Khemawoot, Nalinee Aswapokee, Surapee Tiengrim, Siriporn Fungwitthaya Jan 2002

In Vitro Study Of The Combination Between P-Lactams And Aminoglycosides To Eradicate Escherichia Coli From Sepsis Patients(การใช้เบต้าแลคแตมร่วมกับอะมโนไกลโคไซด์เพื่อ..., Pisit Khemawoot, Nalinee Aswapokee, Surapee Tiengrim, Siriporn Fungwitthaya

The Thai Journal of Pharmaceutical Sciences

Antimicrobial synergy resulting from combination therapy is often advocated in the treatment of gram negative septicemia. One of the most common regimens used for treating E. coli septicemia is the combination of cefotaxime (CTX) and gentamicin (GEN), wi...


Hydrotropic Solubilization Of Riboflavin By Urea, Nicotinamide And Nicotinamide Analogues In Aqueous Systems(การละลายในนํ้าฃองไรโบฟลาวินโดยสารไฮโดรโทรปิค: ยูเ..., Somlak Kongmuang Jan 2002

Hydrotropic Solubilization Of Riboflavin By Urea, Nicotinamide And Nicotinamide Analogues In Aqueous Systems(การละลายในนํ้าฃองไรโบฟลาวินโดยสารไฮโดรโทรปิค: ยูเ..., Somlak Kongmuang

The Thai Journal of Pharmaceutical Sciences

Aqueous solubility of riboflavin was increased by some pyridine derivatives. It was found that the important part of pyridine molecule for enhancing solubility was the aromatic structure. The amide chain also played more important role than acidic chain...


In Vitro Permeation And Metabolism Of Ethyl Nicotinate In Shed Snake Skin(การซึมผ่านผิวหนังและเมตาบอสิสมของเอธีลนิโคติเนทในคราบงูโดยวิ..., Tanasait Ngawhirunpat, Suwannee Panomsuk, Praneet Opanasopit, Tomomi Hatanaka, Tamotsu Koizumi Jan 2002

In Vitro Permeation And Metabolism Of Ethyl Nicotinate In Shed Snake Skin(การซึมผ่านผิวหนังและเมตาบอสิสมของเอธีลนิโคติเนทในคราบงูโดยวิ..., Tanasait Ngawhirunpat, Suwannee Panomsuk, Praneet Opanasopit, Tomomi Hatanaka, Tamotsu Koizumi

The Thai Journal of Pharmaceutical Sciences

The species difference characteristics of transdermal permeation of ethyl nicotinate (EN) and its metabohte [nicotinic acid (NA)] were examined in three species of shed snake skin: Elaphae obsoleta, Naja kaouthia and Python molurus bivittatus. In vitro s...


The Enhancing Effects Of Common Pharmaceutical Solvents On The In Vitro Skin Permeation Of Estradiol(ผลเร่งของตัวทำละลายสามัญทางเภสัชกรรมต่อการดูดซึมสู่..., Punolpan Pithayanukul, Nanti Chansri, Kenji Sugibayashi Jan 2002

The Enhancing Effects Of Common Pharmaceutical Solvents On The In Vitro Skin Permeation Of Estradiol(ผลเร่งของตัวทำละลายสามัญทางเภสัชกรรมต่อการดูดซึมสู่..., Punolpan Pithayanukul, Nanti Chansri, Kenji Sugibayashi

The Thai Journal of Pharmaceutical Sciences

Permeation of a model lipophilic drug, estradiol, through newborn pig skin was investigated using Franz’s diffusion cell at 30° c to evaluate the penetration-enhancing effect of common pharmaceutical solvents: ethanol, propylene glycol, isopropyl myri...


Treatment Of Drug Addicts By A Monk At The Temjai Center, Pathumthani Province(การบำบัดรักษาผู้ติดสารเสพติดโดยพระสงฆ์ในศูนย์เต็มใจจังหวัด..., Ruangthip Tunyapisit Jan 2002

Treatment Of Drug Addicts By A Monk At The Temjai Center, Pathumthani Province(การบำบัดรักษาผู้ติดสารเสพติดโดยพระสงฆ์ในศูนย์เต็มใจจังหวัด..., Ruangthip Tunyapisit

The Thai Journal of Pharmaceutical Sciences

A treatm ent and rehabilitation of drug addicts has now been conducted inside and outside health institutions. Public health academ icians pay little attention to "informal" treatm ents initiated by monks. No study has so far been carried out to clarify ...


บทคัดย่อ การประชุมเสนอผลงานวิจัยทางเภสัชศาสตร์ครั้งที่ 19 : 4 ธันวาคม 2545 (เพิ่มเติม), N/A Jan 2002

บทคัดย่อ การประชุมเสนอผลงานวิจัยทางเภสัชศาสตร์ครั้งที่ 19 : 4 ธันวาคม 2545 (เพิ่มเติม), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Key Word Index, Author Index(ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A Jan 2002

Key Word Index, Author Index(ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.