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Lung Paraquat Content And Effects On The Lung Glutathione Antioxidant System, Nadph, And Polyamines Resulting From Intravenous Coinfusion Of Paraquat And Putrescine To Rats, Jacob R. Dunbar

Electronic Theses and Dissertations

Paraquat was administered to male, Sprague-Dawley rats via continous infusion, at dosage rates of 250 (LoPQ) or 500 (HiPQ) nmoles/hr for seven days. The purpose was to characterize the effects of prolonged, low blood levels of the herbicide on selected lung biochemical parameters. The efficacy of putrescine as an inhibitor of pulmonary paraquat accumulation, in vivo, was assessed in these animals by I.V. coinfusion of 2500 or 5000 nmoles putrescine/hr. Dose-dependent levels of both paraquat and putrescine were achieved by 18 hours and were maintained throughout the exposure period. Terminal lung paraquat content was also dose-dependent and up to 18-fold …