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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Role Of Gluk1 Kainate Receptors In Seizures, Epileptic Discharges, And Epileptogenesis, Brita Fritsch, Janine Reis, Maciej Gasior, Rafal M. Kaminski, Michael A. Rogawski
Role Of Gluk1 Kainate Receptors In Seizures, Epileptic Discharges, And Epileptogenesis, Brita Fritsch, Janine Reis, Maciej Gasior, Rafal M. Kaminski, Michael A. Rogawski
Michael A. Rogawski
Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotransmission in brain regions, such as the amygdala and hippocampus, which are relevant to seizures and epilepsy. Here we used 2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (ATPA), a potent and selective agonist of kainate receptors that include the GluK1 subunit, in conjunction with mice deficient in GluK1 and GluK2 kainate receptor subunits to assess the role of GluK1 kainate receptors in provoking seizures and in kindling epileptogenesis. We found that systemic ATPA, acting specifically via GluK1 kainate receptors, causes locomotor arrest and forelimb extension (a unique behavioral characteristic of GluK1 …
Imagining Possibilities For Healthy Appalachian Communities In An Emerging Postindustrial Landscape, Brian Hoey
Imagining Possibilities For Healthy Appalachian Communities In An Emerging Postindustrial Landscape, Brian Hoey
Brian A. Hoey, Ph.D.
This paper explores how community might be re-imagined to promote incipient social and economic agendas born increasingly of broad-minded citizen initiatives within the Appalachian region aimed at what is generally understood as “development,” but of a form distinct from the prevailing models of a more industrial age. I would like to ask whether a city like Huntington, West Virginia can emerge as a progressive example of what we might term postindustrial, urban regeneration and perhaps what we might call community healing—specifically through grassroots movement now finding local governmental support in collective attempts to transform this place from one defined primarily …