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Pharmacology, Toxicology and Environmental Health Commons™

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2014

Articles 1 - 3 of 3

Full-Text Articles in Pharmacology, Toxicology and Environmental Health

Role Of Gluk1 Kainate Receptors In Seizures, Epileptic Discharges, And Epileptogenesis, Brita Fritsch, Janine Reis, Maciej Gasior, Rafal M. Kaminski, Michael A. Rogawski Apr 2014

Role Of Gluk1 Kainate Receptors In Seizures, Epileptic Discharges, And Epileptogenesis, Brita Fritsch, Janine Reis, Maciej Gasior, Rafal M. Kaminski, Michael A. Rogawski

Michael A. Rogawski

Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotransmission in brain regions, such as the amygdala and hippocampus, which are relevant to seizures and epilepsy. Here we used 2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (ATPA), a potent and selective agonist of kainate receptors that include the GluK1 subunit, in conjunction with mice deficient in GluK1 and GluK2 kainate receptor subunits to assess the role of GluK1 kainate receptors in provoking seizures and in kindling epileptogenesis. We found that systemic ATPA, acting specifically via GluK1 kainate receptors, causes locomotor arrest and forelimb extension (a unique behavioral characteristic of GluK1 …

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An Evaluation Of Mercury Concentrations In Three Brands Of Canned Tuna, Shawn Gerstenberger, Adam Martinson, Joanna Kramer Mar 2014

An Evaluation Of Mercury Concentrations In Three Brands Of Canned Tuna, Shawn Gerstenberger, Adam Martinson, Joanna Kramer

Shawn Gerstenberger

There is widespread concern over the presence of Hg in fish consumed by humans. While studies have been focused on determining the Hg concentration in sport fish and some commercial fish, little attention has been directed to canned tuna; it is widely held that concentrations are low. In the present study, the amount of Hg present in canned tuna purchased in Las Vegas, Nevada, USA, was examined, and the brand, temporal variation, type, and packaging medium impacts on Hg concentrations in tuna were explored. A significant (p < 0.001) brand difference was noted: Brand 3 contained higher Hg concentrations ($\bar x$ …

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Imagining Possibilities For Healthy Appalachian Communities In An Emerging Postindustrial Landscape, Brian Hoey Jan 2014

Imagining Possibilities For Healthy Appalachian Communities In An Emerging Postindustrial Landscape, Brian Hoey

Brian A. Hoey, Ph.D.

This paper explores how community might be re-imagined to promote incipient social and economic agendas born increasingly of broad-minded citizen initiatives within the Appalachian region aimed at what is generally understood as “development,” but of a form distinct from the prevailing models of a more industrial age. I would like to ask whether a city like Huntington, West Virginia can emerge as a progressive example of what we might term postindustrial, urban regeneration and perhaps what we might call community healing—specifically through grassroots movement now finding local governmental support in collective attempts to transform this place from one defined primarily …

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