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Full-Text Articles in Human and Clinical Nutrition
Predicting Personalized Responses To Dietary Fiber Interventions: Opportunities For Modulation Of The Gut Microbiome To Improve Health, Car Reen Kok, Devin J. Rose, Robert Hutkins
Predicting Personalized Responses To Dietary Fiber Interventions: Opportunities For Modulation Of The Gut Microbiome To Improve Health, Car Reen Kok, Devin J. Rose, Robert Hutkins
Department of Nutrition and Health Sciences: Faculty Publications
Inadequate dietary fiber consumption has become common across industrialized nations, accompanied by changes in gut microbial composition and a dramatic increase in chronic metabolic diseases.The human gut microbiome harbors genes that are required for the digestion of fiber, resulting in the production of end products that mediate gastrointestinal and systemic benefits to the host. Thus, the use of fiber interventions has attracted increasing interest as a strategy to modulate the gut microbiome and improve human health. However, considerable interindividual differences in gut microbial composition have resulted in variable responses toward fiber interventions. This variability has led to observed nonresponder individuals …
Potential Of Prebiotic Butyrogenic Fibers In Parkinson’S Disease, Thaisa M. Cantu-Jungles, Heather Rasmussen, Bruce R. Hamaker
Potential Of Prebiotic Butyrogenic Fibers In Parkinson’S Disease, Thaisa M. Cantu-Jungles, Heather Rasmussen, Bruce R. Hamaker
Department of Nutrition and Health Sciences: Faculty Publications
Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. Recent evidence supports the involvement of the gastrointestinal tract in PD pathogenesis, including alterations in microbiota and intestinal permeability. Apart from being the preferred energy source for colonic epithelial cells, butyrate is involved in anti-inflammatory, enteroendocrine and epigenetic mechanisms that influence colonic and systemic health, including brain function. A few studies using oral administration of sodium butyrate indicate beneficial effects in PD animal models; however, prebiotic fibers that generate butyrate locally in the gut may be more effective. The design and selection of …
Starch-Entrapped Microsphere Fibers Improve Bowel Habit But Do Not Exhibit Prebiotic Capacity In Those With Unsatisfactory Bowel Habits: A Phase I, Randomized, Double-Blind, Controlled Human Trial, Heather E. Rasmussen, Bruce Hamaker, Kumar B. Rajan, Ece Mutlu, Stefan J. Green, Michael Brown, Amandeep Kaur, Ali Keshavarzian
Starch-Entrapped Microsphere Fibers Improve Bowel Habit But Do Not Exhibit Prebiotic Capacity In Those With Unsatisfactory Bowel Habits: A Phase I, Randomized, Double-Blind, Controlled Human Trial, Heather E. Rasmussen, Bruce Hamaker, Kumar B. Rajan, Ece Mutlu, Stefan J. Green, Michael Brown, Amandeep Kaur, Ali Keshavarzian
Department of Nutrition and Health Sciences: Faculty Publications
Approximately one-third of individuals in the United States experience unsatisfactory bowel habits, and dietary intake, especially one low in fiber, could be partly responsible. We hypothesized that intake of a fermentable fiber (starch-entrapped microspheres, SM) that has a delayed, slow fermentation profile in vitro would improve bowel habit while exhibiting prebiotic capacity in those with self-described unsatisfactory bowel habits, all with minimal adverse effects. A total of 43 healthy volunteers completed a 3-month,double-blind, parallel-arm randomized clinical trial to assess the ability of a daily dose (9 or 12 g) of SM vs. psyllium (12 g) to improve bowel habit, including …