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Epigallocatechin-3-Gallate Reduces Fat Accumulation In Caenorhabditis Elegans, Jinning Liu
Epigallocatechin-3-Gallate Reduces Fat Accumulation In Caenorhabditis Elegans, Jinning Liu
Masters Theses
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is a polyphenol that is most abundant in tea. It has been shown from many studies that consumption of EGCG can contribute to weight loss, however, the underlying mechanism is not fully understood. To determine how EGCG acts to reduce fat, an organism model Caenorhabditis elegans (C. elegans) is introduced, which is a useful animal system in exploring crucial biological mechanisms that are readily applicable to humans. In this study, different strains were raised for two days on a diet with or without 100µM and 200µM EGCG treatment: N2 (i.e., wild …