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Full-Text Articles in Molecular and Cellular Neuroscience
Genetic Determinants Of Primary Nociceptor Sensitivity In Drosophila Melanogaster, Christine Hale
Genetic Determinants Of Primary Nociceptor Sensitivity In Drosophila Melanogaster, Christine Hale
Electronic Theses and Dissertations
Abnormal pain affects ~50 million adults nationwide. With many of the current treatment options for chronic pain, such as opioid analgesics, carrying side effects such as the threat for addiction, research into safer and more effective options for chronic pain relief is crucial. Abnormal alterations in nociceptive sensitivity, which is the sensitivity of peripheral sensory neurons that detect noxious stimuli, can underlie, and perpetuate chronic pain. However, much is still unknown about the mechanism of how these abnormal alterations in sensitivity occur. To help elucidate genetic components controlling nociceptive sensitivity, the Drosophila melanogaster larval nociception model has been used …
Genetic Circadian Mosaics And The Clock Network’S Contributions To Sleep, Lukasz Widziszewski
Genetic Circadian Mosaics And The Clock Network’S Contributions To Sleep, Lukasz Widziszewski
Dissertations, Theses, and Capstone Projects
Circadian rhythms are physiological and behavioral changes which follow a 24-hour cycle. Drosophila Melanogaster’s circadian clock neuronal network (CCNN) has been identified and several subpopulations have been characterized based on previous studies; the classifications of subpopulations of neurons within the CCNN are based on a return of anticipatory locomotor activity preceding the two daily light transitions (Lights on = dawn/Lights off = dusk). The neurons responsible for the return of anticipatory morning locomotor activity have been referred to as the M-cells, the group of neurons known to rescue evening anticipatory locomotor activity have been termed the E-cells. In this …