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Molecular and Cellular Neuroscience Commons™
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Full-Text Articles in Molecular and Cellular Neuroscience
Reversal Of Neurodegeneration By Engineered Monocytes In Alzheimer’S Disease, Chao-Hsien Chen
Reversal Of Neurodegeneration By Engineered Monocytes In Alzheimer’S Disease, Chao-Hsien Chen
Dissertations & Theses (Open Access)
The health challenges posed by Alzheimer’s disease (AD) continue to grow as societies age worldwide. Accumulation of Tau-associated pathology correlates with clinical cognitive deterioration in AD. Resident myeloid cells within the central nervous system (CNS) have a limited capacity to uptake and degrade Tau; however, the resulting secretion of proinflammatory cytokines only acts to accelerate neurodegeneration. Therapeutic antibodies can reduce the neurotoxic oligomeric form of Tau (o-Tau), but in doing so they also aggravate inflammation. Attenuating mutation of the antibody Fc region can silence inflammation but also eliminates its capacity to mediate o-Tau clearance by CNS myeloid cells. Thus, there …
Aci-35 And Aadvac1 Active Immunotherapy As Preventative Treatment Options For Chronic Traumatic Encephalopathy, Emily C. Boehlein
Aci-35 And Aadvac1 Active Immunotherapy As Preventative Treatment Options For Chronic Traumatic Encephalopathy, Emily C. Boehlein
Selected Honors Theses
One of the most common, as well as one of the most dangerous injuries amongst athletes today is mild traumatic brain injury (mTBI), commonly known as concussion. Aside from physical symptoms such as nausea, dizziness, and headaches; concussions have can have longterm effects on brain physiology. A common neurological disease that can result from multiple concussions is Chronic Traumatic Encephalopathy (CTE), characterized by symptoms such as severe depression, anxiety, confusion, and aggression; amongst others.1 On the cellular level, CTE is classified by a unique pathway that leads to the hyperphosphorylation of tau protein and subsequent clumping of tau-containing neurofibrillary tangles …
Serum-Based Biomarkers And Magnetic Resonance Imaging Following Mild Traumatic Brain Injury In Collegiate Athletes Post Return-To-Play, Taylor R. Susa
Serum-Based Biomarkers And Magnetic Resonance Imaging Following Mild Traumatic Brain Injury In Collegiate Athletes Post Return-To-Play, Taylor R. Susa
All NMU Master's Theses
Recently there has been an increase in the use of MRI (Magnetic Resonance Imaging), to measure the effects of traumatic brain injury (TBI). Proteins such as BDNF, S100B, UCH-L1, and Tau have been found to have altered levels in blood serum after TBI. However, there is limited knowledge about the relationship between serum-based and MRI-based biomarkers in concussed athletes post return-to-play. This study aimed to bridge this gap by collecting serum samples from 42 participants across two groups. The first group (n = 21) consisted of recently cleared to return-to-play collegiate athletes after experiencing a sports-related concussion. The second group …