Open Access. Powered by Scholars. Published by Universities.®
Molecular and Cellular Neuroscience Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 2 of 2
Full-Text Articles in Molecular and Cellular Neuroscience
The Expression Of Mtor And Trib3 In Oligodendrocyte Lineage Cells, Katie Lazur
The Expression Of Mtor And Trib3 In Oligodendrocyte Lineage Cells, Katie Lazur
Senior Theses and Projects
Oligodendrocytes are a type of glial cell in the central nervous system that are responsible for producing the myelin sheath which allows for faster neuronal firing rates. Myelin production is a metabolically expensive process, which requires the oligodendrocytes to be aware of the nutrients are available to them. It has been demonstrated that the mammalian target of Rapamycin (mTOR) is required for the later stages of maturation in oligodendrocytes. However, when mTOR is inhibited by Rapamycin in the early stages of oligodendrocyte development, the oligodendrocytes are still able to fully differentiate. Tribbles Homolog 3 (Trib3) is a pseudo …
Amino Acid Sensing Ability By The Mechanistic Target Of Rapamycin In Oligodendrocytes, Emma England
Amino Acid Sensing Ability By The Mechanistic Target Of Rapamycin In Oligodendrocytes, Emma England
Senior Theses and Projects
Oligodendrocytes (OLs) are a type of glial cell in the central nervous system that require substantial nutrients such as lipids and amino acids to create the extensive, metabolically expensive myelin sheath surrounding the axons of neurons. The mammalian target of rapamycin (mTOR) is a regulatory kinase that is necessary for the maturation of progenitor OLs through their distinct oligo-lineage phases. Amino acids are vital for the functioning of cells. The focus of this study was to determine if mTOR activity is dependent on the availability of leucine, methionine, and alanine. This was assessed by examining the phosphorylation level of the …