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Molecular and Cellular Neuroscience Commons™
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Full-Text Articles in Molecular and Cellular Neuroscience
Noradrenergic Regulation Of Decision-Making In Female And Male Rats, Emma S. Dauster
Noradrenergic Regulation Of Decision-Making In Female And Male Rats, Emma S. Dauster
Doctoral Dissertations
Decision-making is regulated by many associated brain regions, including the locus coeruleus (LC) and the prefrontal cortex (PFC). Disruptions in decision-making are a key feature of many disorders including attention-deficit/hyperactivity disorder which is disproportionately diagnosed in one sex over another for reasons unknown. LC or its primary neurotransmitter norepinephrine (NE) have been implicated in the etiology or treatment of disrupted decision-making. Understanding the relationship among LC, PFC, and decision-making across sexes may provide insight into the basic neurobiology of cognition and disorders that lead to disrupted decision making. There are sex differences in LC anatomy, however studies investigating sex differences …
Sex Differences In Estradiol Signaling In The Zebra Finch (Taeniopygia Gutatta) Auditory Cortex, Amanda Krentzel
Sex Differences In Estradiol Signaling In The Zebra Finch (Taeniopygia Gutatta) Auditory Cortex, Amanda Krentzel
Doctoral Dissertations
Although several sex differences have been described in brain structure, function, and development, sex as a biological factor is underrepresented in neuroscience studies. In the mammalian brain, there are sex differences in the mechanism of rapid estradiol actions on neuronal physiology. In the songbird, the brain is a major source of estradiol production, and estradiol rapidly modulates auditory responsiveness through dynamic changes and an unknown receptor mechanism. I set out to determine if there are sex differences in rapid estradiol modulation of auditory cortical activity, as has been shown in other systems. I tested this hypothesis through three aims: 1) …