Open Access. Powered by Scholars. Published by Universities.®
Molecular and Cellular Neuroscience Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Estradiol (2)
- Norepinephrine (2)
- 2AFC (1)
- Alcohol metabolism (1)
- Aromatase (1)
-
- Attention (1)
- Audition (1)
- Avian (1)
- Brain (1)
- Circadian (1)
- Computational (1)
- Corazonin (1)
- Corazonin receptor (1)
- Coupling (1)
- Dopamine (1)
- Duper (1)
- Estrogen (1)
- Evolution (1)
- GPCR (1)
- Hearing (1)
- Hormone (1)
- Learning (1)
- Locus coeruleus (1)
- MECP2 (1)
- Mutant (1)
- Neuroethology (1)
- Neuromodulator (1)
- Neuropeptide (1)
- Neurosteroid (1)
- Noradrenaline (1)
Articles 1 - 7 of 7
Full-Text Articles in Molecular and Cellular Neuroscience
Noradrenergic Regulation Of Decision-Making In Female And Male Rats, Emma S. Dauster
Noradrenergic Regulation Of Decision-Making In Female And Male Rats, Emma S. Dauster
Doctoral Dissertations
Decision-making is regulated by many associated brain regions, including the locus coeruleus (LC) and the prefrontal cortex (PFC). Disruptions in decision-making are a key feature of many disorders including attention-deficit/hyperactivity disorder which is disproportionately diagnosed in one sex over another for reasons unknown. LC or its primary neurotransmitter norepinephrine (NE) have been implicated in the etiology or treatment of disrupted decision-making. Understanding the relationship among LC, PFC, and decision-making across sexes may provide insight into the basic neurobiology of cognition and disorders that lead to disrupted decision making. There are sex differences in LC anatomy, however studies investigating sex differences …
Phenotyping Regression In A Female Mouse Model For Rett Syndrome Using Computational Neuroethology Tools, Michael J. Mykins
Phenotyping Regression In A Female Mouse Model For Rett Syndrome Using Computational Neuroethology Tools, Michael J. Mykins
Doctoral Dissertations
Regression is defined as loss of acquired skills over time and is a key feature of many neurodevelopmental disorders such as Rett syndrome (RTT). RTT is caused by mutations in the X-linked gene Methyl CpG-Binding Protein 2 (MECP2) and is characterized by a period of typical development with subsequent regression of previously acquired motor and speech skills in girls. In human and animal models, it is clear syndromic phenotypes are dynamic over time but phenotyping regression over time in animal models has remained elusive. Lack of established timelines to study the molecular, cellular, and behavioral features of regression in female …
The Neurobiological Underpinnings Of Depression-Related Maternal Behavior Deficits, Sarah B. Winokur
The Neurobiological Underpinnings Of Depression-Related Maternal Behavior Deficits, Sarah B. Winokur
Doctoral Dissertations
Maternal caregiving is a dynamic process that requires extensive cognitive, motivational, and affective processing. World-wide, approximately 17% of mothers are diagnosed with postpartum depression yearly (Wang et al., 2021). Untreated, mothers with postpartum depression experience deficits in cognition, motivation, affect, and parenting (Arteche et al., 2011; Dix and Meunier, 2009; Lovejoy et al., 2000). Although postpartum depression is related to compromised parenting, to date, few studies have examined the neurobiological mechanisms by which maternal behavior is compromised in postpartum depression (Field, 2010; Murray et al., 1996). This dissertation aims to examine how depression neurobiologically disrupts parenting abilities. These studies …
How Do Adult Songbirds Learn New Sounds? Using Neuromodulators To Probe The Function Of The Auditory Association Cortex, Matheus Macedo-Lima
How Do Adult Songbirds Learn New Sounds? Using Neuromodulators To Probe The Function Of The Auditory Association Cortex, Matheus Macedo-Lima
Doctoral Dissertations
The ability to associate sounds and outcomes is vital in the life history of many species. Animals constantly assess the soundscape for cues associated with threats, competitors, allies, mates or prey, and experience is crucial for those associations. For vocal learning species such as humans and songbirds, learning sounds (i.e. perception and association learning) is also the first step in the process of vocal learning. Auditory learning is thought to depend on high-order cortical brain structures, where sounds and meaning are bound. In songbirds, the caudomedial nidopallium (NCM) is part of the auditory association cortex and is known to be …
The Cellular Context Of Estradiol Regulation In The Zebra Finch Auditory Forebrain, Maaya Ikeda
The Cellular Context Of Estradiol Regulation In The Zebra Finch Auditory Forebrain, Maaya Ikeda
Doctoral Dissertations
Estradiol, traditionally known as a hormone that communicates with distant cells in the body, is also synthesized locally in the brain to act as a neuromodulator. Neuromodulators differ from neurotransmitters in that they simultaneously affect a population of neurons and their actions are not limited to the synapse. One of the many effects of estradiol signaling is rapid modulation of auditory processing in response to external stimuli. The enzyme required for estradiol synthesis, aromatase, is highly expressed in the regions that are involved in higher-order processing of sounds in humans and songbirds. Since zebra finches, a type of songbird, are …
Behavioral, Neurobiological, And Genetic Analysis Of The Circadian Mutant Duper, Emily Nicole Corbett Manoogian
Behavioral, Neurobiological, And Genetic Analysis Of The Circadian Mutant Duper, Emily Nicole Corbett Manoogian
Doctoral Dissertations
The recently discovered circadian mutant hamster duper has a short period of ~23 hours and exhibits exaggerated phase shifts in response to a 15-min light pulse. To increase the understanding of the duper mutation, I performed behavioral, neurobiological, and genetic experiments. Behavioral studies using photic and non-photic stimuli found that large phase shifts exhibited by duper hamsters are specific to photic cues, but not to phase. Additionally, 2/3 of duper hamsters, but no WTs, displayed transient ultradian wheel-running patterns when transferred from light to dark at CT 18. This suggests that the mutation may weaken coupling among components of the …
Functional Analysis Of Corazonin And Its Receptor In Drosophila Melanogaster, Kai Sha
Functional Analysis Of Corazonin And Its Receptor In Drosophila Melanogaster, Kai Sha
Doctoral Dissertations
Corazonin (Crz) is an amidated undecapeptide originally isolated from the American cockroach. It has been shown to affect diverse physiological functions in a species-specific manner. However, the functionality of Crz in Drosophila melanogaster has not yet been determined. To gain insight into the role of Crz signaling in vivo, Crz and CrzR null alleles were obtained by transposable element mobilization. Flies carrying a deficiency uncovering Crz and pr-set7 loci were generated via P-element excision, and the latter was rescued by wild-type pr-set7 transgene. A mutation of Crz receptor (CrzR) was generated by Minos-element mobilization from …