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Characterization Of And Cellular Mechanisms Underlying Spinal Non-Viral Interleukin-10 Gene Therapy Formulated With D-Mannose For Treatment Of Peripheral Neuropathic Pain, Arden G. Vanderwall
Characterization Of And Cellular Mechanisms Underlying Spinal Non-Viral Interleukin-10 Gene Therapy Formulated With D-Mannose For Treatment Of Peripheral Neuropathic Pain, Arden G. Vanderwall
Biomedical Sciences ETDs
Anti-inflammatory intrathecal non-viral interleukin-10 (IL-10) gene therapy provides enduring relief of chronic pain in numerous animal pain models. Co-administration of the mannose receptor (MR) ligand D-mannose (DM) improves non-viral IL-10 gene therapeutic efficacy, but questions remain regarding which pain-relevant tissues are critical for non-viral transgene expression resulting in long-lasting pain relief. Additionally, the role of endogenous IL-10 in non-viral IL-10 therapeutic effects is completely unknown.
Chapter I is an Introduction to the studies detailed in this dissertation, providing a historical perspective of the field of neuroinflammation and a framework upon which neuroimmune processes intersect with mechanisms underlying pathological pain. The …