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Aging. Brain injury. Subventricular Zone. Ependymal Cells. Lateral Ventricle. Ventriculomegaly. Mouse.
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Full-Text Articles in Developmental Neuroscience
Characterization Of The Ependymal Barrier Due To Human Aging And Injury In Murine Models, Ye Sun
Characterization Of The Ependymal Barrier Due To Human Aging And Injury In Murine Models, Ye Sun
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Ventriclulomegaly, or the expansion of the ventricles in the brain, is a phenomenon associated with age and injury to the brain. The ependymal layer that encases the ventricles displays certain degrees of plasticity and regenerative ability due to its associated stem cell niche, the subventricular zone (SVZ). Previous research in the Conover Lab has shown that in the mouse, which maintains an actively proliferating SVZ into adulthood, there is an intact ependymal monolayer throughout normal aging, with maintained lateral ventricle size with some degree of stretching. In contrast, the human SVZ declines in proliferative capacity after infancy, and age-related changes …