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Articles 1 - 16 of 16
Full-Text Articles in Developmental Neuroscience
Effects Of Neonatal Hypoxic Ischemic Brain Injury On Spatial Working Memory, Amanda L. Smith
Effects Of Neonatal Hypoxic Ischemic Brain Injury On Spatial Working Memory, Amanda L. Smith
Master's Theses
Children born prematurely or at very low birth weight (VLBW) have an increased risk for hypoxic ischemic brain injury (HI). HI refers to a lack of adequate blood and oxygen flow in the brain. HI can also occur in the term infant due to birth complications such as prolonged labor, placental dysfunction, or cord prolapse. In both populations (though exact patterns of neuropathology vary) brain damage is likely to occur in the form of decreased hippocampal and cortical volume, and enlargement of the ventricles (Kesler et al., 2004, Nagy et al., 2009). Resulting neuropathology can in turn lead to cognitive …
Brief Embryonic Strychnine Exposure In Zebrafish Causes Long-Term Adult Behavioral Impairment With Indications Of Embyronic Synaptic Changes, Nicole M. Roy, Brianna Arpie, Joseph Lugo, Elwood Linney, Edward D. Levin, Daniel Cerutti
Brief Embryonic Strychnine Exposure In Zebrafish Causes Long-Term Adult Behavioral Impairment With Indications Of Embyronic Synaptic Changes, Nicole M. Roy, Brianna Arpie, Joseph Lugo, Elwood Linney, Edward D. Levin, Daniel Cerutti
Biology Faculty Publications
Zebrafish provide a powerful model of the impacts of embryonic toxicant exposure on neural development that may result in long-term behavioral dysfunction. In this study, zebrafish embryos were treated with 1.5mM strychnine for short embryonic time windows to induce transient changes in inhibitory neural signaling, and were subsequently raised in untreated water until adulthood. PCR analysis showed indications that strychnine exposure altered expression of some genes related to glycinergic, GABAergic and glutamatergic neuronal synapses during embryonic development. In adulthood, treated fish showed significant changes in swimming speed and tank diving behavior compared to controls. Taken together, these data show that …
Diffusion Barriers Of The Lateral Ventricular System, Anitha Saravanakumar
Diffusion Barriers Of The Lateral Ventricular System, Anitha Saravanakumar
Master's Theses
Adult neurogenesis in mammalian brain has become a well-accepted phenomenon. The neural stem cells in the sub ventricular zone (SVZ) along the lateral wall of the lateral ventricle, the largest germinal center of adult neurogenesis, are maintained by the neural stem cell niche. One prominent feature of the niche is its close proximity to the cerebral spinal fluid (CSF). The role of micromolecules (such as ions, water and gases) present in the CSF and diffusing through the lateral ventricular wall and how the stem cell micro-environment is maintained is poorly understood. The cytoarchitecture of the lateral ventricular wall with a …
Autism Spectrum Disorders In Hispanics And Non-Hispanics, Virginia Chaidez, Robin L. Hansen, Irva Hertz-Picciotto
Autism Spectrum Disorders In Hispanics And Non-Hispanics, Virginia Chaidez, Robin L. Hansen, Irva Hertz-Picciotto
Department of Nutrition and Health Sciences: Faculty Publications
Objectives: To compare differences in autism between Hispanics and non-Hispanics. We also examined the relationship between multiple language exposure and language function and scores of children. Methods: The Childhood Autism Risks from Genetics and the Environment (CHARGE) study is an ongoing population-based case-control study with children sampled (n = 1061) from three strata: those with autism (AU) or autism spectrum disorder (ASD); developmental delay (DD); or the general population (GP). Results: Non-Hispanic cases demonstrated higher cognitive composite scores for the Mullen Scales of Early Learning (MSEL). There were significant associations between multiple language exposure and MSEL subscales for receptive …
Effect Of Nicotine On Body Composition, Laura O'Dell
Effect Of Nicotine On Body Composition, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
The Effects Of Prenatal Exposure To Altered Melatonin Levels On Hippocampal Gene Expression In The Male Rat, Anna Uehara
The Effects Of Prenatal Exposure To Altered Melatonin Levels On Hippocampal Gene Expression In The Male Rat, Anna Uehara
Honors Theses
The stability of the circadian rhythm for mammals depends on the levels of serotonin and melatonin, neurohormones that signal for lightness and darkness, respectively. Disruption in the stability of neurohormones has been shown to be a critical factor in psychopathological disorders in humans. For example, altering levels of melatonin in utero through administration of melatonin or the melatonin receptor antagonist, luzindole, has been shown to cause changes in developmental growth and adult behavior in the male rat. Analysis of relative adult hippocampal gene expression with RT-PCR revealed differences in ARNTL expression that suggested abnormality in clock gene expression of the …
Structure-Function Analysis Of Nel, A Thrombospondin-1-Like Glycoprotein Involved In Neural Development And Functions, Masaru Nakamoto
Structure-Function Analysis Of Nel, A Thrombospondin-1-Like Glycoprotein Involved In Neural Development And Functions, Masaru Nakamoto
Biology Faculty Publications
Nel (neural epidermal growth factor (EGF)-like molecule) is a multimeric, multimodular extracellular glycoprotein with heparin-binding activity and structural similarities to thrombospondin-1. Nel is predominantly expressed in the nervous system and has been implicated in neuronal proliferation and differentiation, retinal axon guidance, synaptic functions, and spatial learning. The Nel protein contains an N-terminal thrombospondin-1 (TSP-N) domain, five cysteine-rich domains, and six EGF-like domains. However, little is known about the functions of specific domains of the Nel protein. In this study, we have performed structure-function analysis of Nel, by using a series of expression constructs for different regions of the Nel protein. …
The Evolved Apprentice. How Evolution Made Humans Unique, Mirko Farina
The Evolved Apprentice. How Evolution Made Humans Unique, Mirko Farina
Mirko Farina
No abstract provided.
Perception, Action, And Consciousness: Sensorimotor Dynamics And Two Visual Systems, Mirko Farina
Perception, Action, And Consciousness: Sensorimotor Dynamics And Two Visual Systems, Mirko Farina
Mirko Farina
No abstract provided.
Do Ssds Extend The Conscious Mind?, Mirko Farina, Julian Kiverstein
Do Ssds Extend The Conscious Mind?, Mirko Farina, Julian Kiverstein
Mirko Farina
Is the brain the biological substrate of consciousness? Most naturalistic philosophers of mind have supposed that the answer must obviously be «yes » to this question. However, a growing number of philosophers working in 4e (embodied, embedded, extended, enactive) cognitive science have begun to challenge this assumption, arguing instead that consciousness supervenes on the whole embodied animal in dynamic interaction with the environment. We call views that share this claim dynamic sensorimotor theories of consciousness (DSM). Clark (2009), a founder and leading proponent of the hypothesis of the extended mind, demurs, arguing that as matter of fact the biology of …
Distinctive Neural Processes During Learning In Autism, Sarah Schipul, Diane Williams, Timothy Keller, Nancy Minshew, Marcel Just
Distinctive Neural Processes During Learning In Autism, Sarah Schipul, Diane Williams, Timothy Keller, Nancy Minshew, Marcel Just
Marcel Adam Just
No abstract provided.
Brain Activation For Language Dual-Tasking: Listening To Two People Speak At The Same Time And A Change In Network Timing, Augusto Buchweitz, Timothy Keller, Ann Meyler, Marcel Just
Brain Activation For Language Dual-Tasking: Listening To Two People Speak At The Same Time And A Change In Network Timing, Augusto Buchweitz, Timothy Keller, Ann Meyler, Marcel Just
Marcel Adam Just
No abstract provided.
Autism As A Neural Systems Disorder: A Theory Of Frontal-Posterior Underconnectivity, Marcel Just, Timothy Keller, Vicente Malave, Rajesh Kana, Sashank Varma
Autism As A Neural Systems Disorder: A Theory Of Frontal-Posterior Underconnectivity, Marcel Just, Timothy Keller, Vicente Malave, Rajesh Kana, Sashank Varma
Marcel Adam Just
No abstract provided.
An Fmri Investigation Of Analogical Mapping In Metaphor Comprehension: The Influence Of Context And Individual Cognitive Capacities On Processing Demands., Chantel Prat, Robert Mason, Marcel Just
An Fmri Investigation Of Analogical Mapping In Metaphor Comprehension: The Influence Of Context And Individual Cognitive Capacities On Processing Demands., Chantel Prat, Robert Mason, Marcel Just
Marcel Adam Just
No abstract provided.
Exploring Commonalities Across Participants In The Neural Representation Of Objects, Svetlana V. Shinkareva, Vicente L. Malave, Marcel Adam Just, Tom M. Mitchell
Exploring Commonalities Across Participants In The Neural Representation Of Objects, Svetlana V. Shinkareva, Vicente L. Malave, Marcel Adam Just, Tom M. Mitchell
Marcel Adam Just
No abstract provided.
Identifying Bilingual Semantic Neural Representations Across Languages, Augusto Buchweitz, Svetlana V. Shinkareva, Robert A. Mason, Tom M. Mitchell, Marcel Adam Just
Identifying Bilingual Semantic Neural Representations Across Languages, Augusto Buchweitz, Svetlana V. Shinkareva, Robert A. Mason, Tom M. Mitchell, Marcel Adam Just
Marcel Adam Just
No abstract provided.