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Full-Text Articles in Behavioral Neurobiology
Long-Term Impacts Of Acute Stressor Exposure On Locus Coeruleus Function And Anxiety-Like Behavior In Rats, Olga Borodovitsyna
Long-Term Impacts Of Acute Stressor Exposure On Locus Coeruleus Function And Anxiety-Like Behavior In Rats, Olga Borodovitsyna
Graduate School of Biomedical Sciences Theses and Dissertations
Stress is a physiological state characterized by behavioral arousal that occurs during exposure to harmful or threatening stimuli, and usually facilitates an adaptive behavioral response. The persistence of stress sometimes causes it to become maladaptive, potentially contributing to disease development, including physiological complications with altered neuroendocrine signaling and impaired function of organ systems, and psychological conditions including depression and anxiety. Anxiety disorders in particular are associated with a history of stress and are the most common class of mental disorders, with a lifetime prevalence of 33.7% in the general population. The locus coeruleus (LC) is a major node in the …
Interactions Between The Hypothalamic-Pituitary-Adrenal (Hpa) Axis, Oxytocin System, And Behavior In Differently Reared Rhesus Monkeys (Macaca Mulatta), Amanda F. Hamel
Interactions Between The Hypothalamic-Pituitary-Adrenal (Hpa) Axis, Oxytocin System, And Behavior In Differently Reared Rhesus Monkeys (Macaca Mulatta), Amanda F. Hamel
Doctoral Dissertations
Adverse experiences that occur during early critical periods of development modify activity of neuroendocrine systems, such as the hypothalamic-pituitary-adrenal (HPA) axis and oxytocin system. This dissertation examines the effects of nursery rearing, an established model of adverse early experiences, on activity of the HPA axis and oxytocin system in infant and adult rhesus macaques (Macaca mulatta). In addition, influence of oxytocin system activity on the HPA axis and behavioral reactivity was examined. In infant monkeys, nursery-rearing was associated with lower HPA axis, yet higher oxytocin system activity, following the acute stress of developmental assessment. Nursery rearing may result …