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Full-Text Articles in Behavioral Neurobiology
Age Impacts Perineuronal Net Density In The Somatosensory Genital Cortex Independently Of Gonadal Steroid Hormones, Ian D. Warren
Age Impacts Perineuronal Net Density In The Somatosensory Genital Cortex Independently Of Gonadal Steroid Hormones, Ian D. Warren
Masters Theses
A hallmark of pubertal development is the rise in gonadal hormone secretions and the subsequent onset of sexual behavior. The size of the somatosensory genital cortex increases in response to both this rise in gonadal steroid hormones and sexual experience. However, whether specific markers of brain plasticity are similarly impacted by gonadal hormones during puberty is not known. Perineuronal nets (PNNs) are specialized extracellular matrix structures that unsheathe neurons as they mature, and their maturation coincides with the closure of sensitive periods across several sensory systems. PNNs in somatosensory cortex, as an example, respond to experience-dependent plasticity. Although experience-depended changes …
Phenotyping Regression In A Female Mouse Model For Rett Syndrome Using Computational Neuroethology Tools, Michael J. Mykins
Phenotyping Regression In A Female Mouse Model For Rett Syndrome Using Computational Neuroethology Tools, Michael J. Mykins
Doctoral Dissertations
Regression is defined as loss of acquired skills over time and is a key feature of many neurodevelopmental disorders such as Rett syndrome (RTT). RTT is caused by mutations in the X-linked gene Methyl CpG-Binding Protein 2 (MECP2) and is characterized by a period of typical development with subsequent regression of previously acquired motor and speech skills in girls. In human and animal models, it is clear syndromic phenotypes are dynamic over time but phenotyping regression over time in animal models has remained elusive. Lack of established timelines to study the molecular, cellular, and behavioral features of regression in female …