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Full-Text Articles in Behavioral Neurobiology
Effects Of Ketogenic Diets On Autistic Symptoms Of Female El Mice, Subrina N. Bisnauth
Effects Of Ketogenic Diets On Autistic Symptoms Of Female El Mice, Subrina N. Bisnauth
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The ketogenic diet (KD) is a restricted carbohydrate, high fat and sufficient protein metabolic therapy that elevates ketones as an alternative fuel source, and that reduces seizures in persons with epilepsy which is often comorbid with autism. Autism is characterized by communication deficits, decreased sociability and repetitive behaviours. A restrictive KD reverses symptoms in the BTBR mouse model of autism but its severity is a factor in its clinical applicability. In a study with the EL mouse model of epilepsy and autism, sex-dependent effects were found where only females displayed the behavioural effects of the KD. In the current study, …