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Articles 1 - 7 of 7
Full-Text Articles in Behavioral Neurobiology
Altered Sensitivity To Cocaine In Adolescent Spontaneously Hypertensive Rats, A Rodent Model Of Attention-Deficit/Hyperactivity Disorder, Ingrid Schoenborn
Altered Sensitivity To Cocaine In Adolescent Spontaneously Hypertensive Rats, A Rodent Model Of Attention-Deficit/Hyperactivity Disorder, Ingrid Schoenborn
Senior Theses and Projects
Adolescents with attention-deficit/hyperactivity disorder (ADHD) are at greater risk for psychostimulant abuse compared to those without ADHD. This may be due to alterations in the mesolimbocortical dopamine system; indeed, psychostimulant-induced dopamine release is greater in adult spontaneously hypertensive rats (SHRs; a rodent model of ADHD) compared to controls. Here, we sought to determine the extent to which neurobehavioral responses to cocaine are altered in adolescent SHRs. To begin to address this question, adolescent male and female SHRs and Sprague Dawley (SD; a reference strain) rats were first assessed for behavioural signs of ADHD, including inattention (Y-maze test) and hyperactivity (open-field …
Cognitive Rehabilitation Of Prospective Memory Deficits After Acquired Brain Injury: Cognitive, Behavioral, And Physiological Measures, Meaghan Race
Senior Theses and Projects
Acquired brain injury (ABI) affects approximately 3.5 million Americans each year and is associated with cognitive and emotional changes. Prospective memory (PM) deficits are important predictors of functioning in daily life for individuals with ABI. Previous studies have shown that cognitive rehabilitation therapy (CRT) via PM training has a high rate of success in improving quality of life, independence and productivity for ABI survivors. There is limited information on utilizing imaging techniques in relation to changes in cognition and behavior following rehabilitation; however, previous studies suggest that imaging provides evidence that CRT could be related to changes to underlying brain …
Development Of An Intrahippocampal Kindling Model Of Epilepsy, Carter F. Jones
Development Of An Intrahippocampal Kindling Model Of Epilepsy, Carter F. Jones
Senior Theses and Projects
Epilepsy is a neurological condition that affects about 1% of the global population. This debilitating condition is associated with overexcitation and ineffective inhibition of neuronal pathways in the brain causing serious and a diverse set of symptoms, most prominently seizures. While some antiepileptic drug (AED) regimes have been proven to be effective in treating this condition, there are many cases where the drugs do not do enough. The ketogenic diet (KD) has been used for decades as an effective anticonvulsant. Its powerful and natural processes result in some patients becoming seizure-free. Sometimes, these patients remain free of seizures even after …
The Effects Of Soil Copper Contamination On Earthworm Cholinergic Transmission, Locomotion And Muscle Physiology, Tommaso Meregalli
The Effects Of Soil Copper Contamination On Earthworm Cholinergic Transmission, Locomotion And Muscle Physiology, Tommaso Meregalli
Senior Theses and Projects
No abstract provided.
Feeling And Speaking: The Role Of Sensory Feedback In Speech, Francesca R. Marino
Feeling And Speaking: The Role Of Sensory Feedback In Speech, Francesca R. Marino
Senior Theses and Projects
Sensory feedback allows talkers to accurately control speech production, and auditory information is the predominant form of speech feedback. When this sensory stream is degraded, talkers have been shown to rely more heavily on somatosensory information. Furthermore, perceptual speech abilities are greatest when both auditory and visual feedback are available. In this study, we experimentally degraded auditory feedback using a cochlear implant simulation and somatosensory feedback using Orajel. Additionally, we placed a mirror in front of the talkers to introduce visual feedback. Participants were prompted to speak under a baseline, feedback degraded, and visual condition; audiovisual speech recordings were taken …
Effects Of Ketogenic Diets On Autistic Symptoms Of Female El Mice, Subrina N. Bisnauth
Effects Of Ketogenic Diets On Autistic Symptoms Of Female El Mice, Subrina N. Bisnauth
Senior Theses and Projects
The ketogenic diet (KD) is a restricted carbohydrate, high fat and sufficient protein metabolic therapy that elevates ketones as an alternative fuel source, and that reduces seizures in persons with epilepsy which is often comorbid with autism. Autism is characterized by communication deficits, decreased sociability and repetitive behaviours. A restrictive KD reverses symptoms in the BTBR mouse model of autism but its severity is a factor in its clinical applicability. In a study with the EL mouse model of epilepsy and autism, sex-dependent effects were found where only females displayed the behavioural effects of the KD. In the current study, …
Determination Of Catecholamine Content Changes In Mouse Brain Following Chronic Ketogenic Diet, Ryan Adams
Determination Of Catecholamine Content Changes In Mouse Brain Following Chronic Ketogenic Diet, Ryan Adams
Senior Theses and Projects
This work investigated the effects of the ketogenic diet on catecholamine concentrations in the brains of mice. The ketogenic diet has been show to modulate the catecholamine concentrations in the cerebrospinal fluid of children as well as altering hippocampal norepinephrine levels in mice. Tissue homogenates of the motor cortex, somatosensory cortex, nucleus accumbens, anterior caudate, posterior caudate and midbrain regions were analyzed using high pressure liquid chromatography to quantitate norepinephrine, dopamine, 3, 4-dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5HIAA), homovanillic acid (HVA) and serotonin (5-HT). No significant differences in catecholamine concentration levels were detected in the tissue homogenates. Analysis of metabolite …