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Full-Text Articles in Behavioral Neurobiology
Altered Sensitivity To Cocaine In Adolescent Spontaneously Hypertensive Rats, A Rodent Model Of Attention-Deficit/Hyperactivity Disorder, Ingrid Schoenborn
Altered Sensitivity To Cocaine In Adolescent Spontaneously Hypertensive Rats, A Rodent Model Of Attention-Deficit/Hyperactivity Disorder, Ingrid Schoenborn
Senior Theses and Projects
Adolescents with attention-deficit/hyperactivity disorder (ADHD) are at greater risk for psychostimulant abuse compared to those without ADHD. This may be due to alterations in the mesolimbocortical dopamine system; indeed, psychostimulant-induced dopamine release is greater in adult spontaneously hypertensive rats (SHRs; a rodent model of ADHD) compared to controls. Here, we sought to determine the extent to which neurobehavioral responses to cocaine are altered in adolescent SHRs. To begin to address this question, adolescent male and female SHRs and Sprague Dawley (SD; a reference strain) rats were first assessed for behavioural signs of ADHD, including inattention (Y-maze test) and hyperactivity (open-field …