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Chemotherapy-Induced Nausea and Vomiting (CINV); Anticipatory Nausea (AN); Estrogens; Estrous Cycle; Sex Differences; Nausea
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Full-Text Articles in Behavioral Neurobiology
The Influence Of Estrogen On Sex Differences In Chemotherapy-Induced Nausea And Vomiting (Cinv), Danna L. Zevy
The Influence Of Estrogen On Sex Differences In Chemotherapy-Induced Nausea And Vomiting (Cinv), Danna L. Zevy
Electronic Thesis and Dissertation Repository
Chemotherapy-induced nausea and vomiting (CINV) is one of the most distressing events that affects the quality of life of cancer patients. Evidence suggests that females are more susceptible to CINV than males, but the mechanism remains unknown. The current thesis examined whether higher levels of circulating estrogens in females contributes to this sex difference. CINV was analyzed in a pediatric oncology population, where it was revealed female patients demonstrate increased delayed CINV relative to male patients, in the post-pubertal age group. CINV was also studied by examining the influence of the estrous cycle on anticipatory nausea (AN) in rats. This …