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Full-Text Articles in Behavioral Neurobiology
Molecular Sites And Mechanisms Of Action Of Alcohol On The Nmda Receptor Glun2b Subunit, Yulin Zhao
Molecular Sites And Mechanisms Of Action Of Alcohol On The Nmda Receptor Glun2b Subunit, Yulin Zhao
Dissertations (1934 -)
Alcohol abuse and alcoholism are behavioral disorders involving altered synaptic transmission in the brain. The N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate-gated ion channel, has been shown to be one of the most important target sites of alcohol in the central nervous system. The NMDA receptor is formed between two obligatory GluN1 subunits and two GluN2 subunits (2A-2D). Previous studies have been mainly focused on the GluN2A subunit-containing NMDA receptor to study the molecular sites and mechanisms of alcohol action on the NMDA receptors. However, a major role for the GluN2B subunits in the action of alcohol has been pointed …