Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Behavioral Neurobiology
Development Of An Intrahippocampal Kindling Model Of Epilepsy, Carter F. Jones
Development Of An Intrahippocampal Kindling Model Of Epilepsy, Carter F. Jones
Senior Theses and Projects
Epilepsy is a neurological condition that affects about 1% of the global population. This debilitating condition is associated with overexcitation and ineffective inhibition of neuronal pathways in the brain causing serious and a diverse set of symptoms, most prominently seizures. While some antiepileptic drug (AED) regimes have been proven to be effective in treating this condition, there are many cases where the drugs do not do enough. The ketogenic diet (KD) has been used for decades as an effective anticonvulsant. Its powerful and natural processes result in some patients becoming seizure-free. Sometimes, these patients remain free of seizures even after …
Determination Of Catecholamine Content Changes In Mouse Brain Following Chronic Ketogenic Diet, Ryan Adams
Determination Of Catecholamine Content Changes In Mouse Brain Following Chronic Ketogenic Diet, Ryan Adams
Senior Theses and Projects
This work investigated the effects of the ketogenic diet on catecholamine concentrations in the brains of mice. The ketogenic diet has been show to modulate the catecholamine concentrations in the cerebrospinal fluid of children as well as altering hippocampal norepinephrine levels in mice. Tissue homogenates of the motor cortex, somatosensory cortex, nucleus accumbens, anterior caudate, posterior caudate and midbrain regions were analyzed using high pressure liquid chromatography to quantitate norepinephrine, dopamine, 3, 4-dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5HIAA), homovanillic acid (HVA) and serotonin (5-HT). No significant differences in catecholamine concentration levels were detected in the tissue homogenates. Analysis of metabolite …