Behavioral Neurobiology Commons^™

Effects Of Chronic Caffeine Administration On Behavioral And Molecular Adaptations To Sensory Contact Model Induced Stress In Adolescent Male Mice, Micheal K. Ibrahim, Mohamed M. Kamal, Rajiv Tikamdas, Roua Aref Nouh, Jiang Tian, Mostafa Sayed

Pharmacy

Previous studies have shown that caffeine attenuates stress-induced mood dysfunction and memory deterioration through neuronal adenosine A2A receptors antagonism. However, whether caffeine exerts this effect through modulating other molecular targets, which interfere with the resilience to social defeat stress in adolescent male mice is unknown. This study was conducted to investigate the role of caffeine in the behavioral responses to social stress induced by the sensory contact model (SCM) and the possible alteration of the gene expression level of Na/K ATPase pump. Adolescent male mice were exposed to SCM for 12 days. Caffeine was administered intraperitoneal daily for 14 days …