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Full-Text Articles in Behavioral Neurobiology
Calcium Imaging Of Central Amygdala Activity After Fentanyl Escalation, Samantha Malone
Calcium Imaging Of Central Amygdala Activity After Fentanyl Escalation, Samantha Malone
Theses and Dissertations--Psychology
Evidence suggests that rats given long access (LgA) sessions to self-administer (SA) opioids escalate their intake, while also showing greater withdrawal severity and drug-induced reinstatement compared to rats maintained on short access (ShA) daily SA sessions. Little is known about the neural changes that occur during opioid escalation that may impact withdrawal and relapse. Past work examining opioid SA using ShA sessions in rodents has identified the central amygdala (CeA) as an area of interest that becomes hyperactive in acute withdrawal and may be involved in the incubation of craving that occurs after protracted withdrawal. However, these studies have not …
Circuits Underlying Serotonin Mediated Sex Differences In Fear Learning, Rebecca Ravenelle
Circuits Underlying Serotonin Mediated Sex Differences In Fear Learning, Rebecca Ravenelle
Dissertations, Theses, and Capstone Projects
Post-traumatic stress disorder (PTSD) is a trauma-related disorder characterized by intense fearful memory formation. Women are twice as likely as men to develop PTSD, indicating there may be sex differences in the underlying neural circuits. Given that serotonin (5-HT) dysfunction is implicated in PTSD, and 5-HT modulates fear learning, we investigated whether there are sex differences in the modulation of fear learning by 5-HT. We administered the selective serotonin reuptake inhibitor (SSRI) citalopram (20mg/kg or 10m/kg, i.p.) once to male and female mice prior to auditory fear conditioning and tested the effects on fear memory the next day. We found …