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Full-Text Articles in Behavioral Neurobiology
Tests And Refinements Of A General Structure-Activity Model For Avian Repellents, Larry Clark, Pankaj Shah
Tests And Refinements Of A General Structure-Activity Model For Avian Repellents, Larry Clark, Pankaj Shah
Larry Clark
We tested the robustness of a structure-activity model for avian trigeminal chemoirritants. Fourteen benzoates and acetophenones were tested using European starlings Sturn us vulgaris as a bioassay. In general. the pre viously proposed model was a reasonable predictor of repellency (i.e., irritant potency). We found that the presence of a phenyl ring was critical to repel lency. Basicity of the molecule is the next most critical feature influencing repellency. The presence of an acidic function within the electron-withdrawing functionality seriously detracts from repellency. The presence or absence of an electron-withdrawing or -donating group may potentiate repellent effects, but its presence …
Avian Chemical Repellency: A Structure-Activity Approach And Implications, Pankaj Shah, Russell Mason, Larry Clark
Avian Chemical Repellency: A Structure-Activity Approach And Implications, Pankaj Shah, Russell Mason, Larry Clark
Larry Clark
Until recently, the discovery of avian sensory repellents has been empirical (MaRnn, AnAmR 'Inn l;qr\r FlR'l), Hm> !ilv!ilr, recent liltudilillil in our laboratory have shown that many avian repellents have similar perceptual and structural properties (Mason et al. 1989; Mason Clark and Shah 1991; Clark and Shah 1991; Clark, Shah and Mason 1991; Shah, Clark and Mason 1991). For example, methyl anthranilate, which has a grapy odor, is repel lent to birds (Kare and Pick, 1960). Ortho-aminoacetophenone has an odor and structure similar to that of methyl anthranilate, differing only in the substitution of a ketone for an ester group …
Ortho-Aminoacetophenone Repellency To Birds: Similiarities To Methyl Antrhanilate, Russell Mason, Larry Clark, Pankaj Shah
Ortho-Aminoacetophenone Repellency To Birds: Similiarities To Methyl Antrhanilate, Russell Mason, Larry Clark, Pankaj Shah
Larry Clark
Methyl anthranilate is an effective bird repellent at concentrations 2:1.0% (g/g). Ortho-ami noacetophenone (OAP) has an odor similar to that of methyl anthranilate and is chemically (structurally) similar. Coincidentally, OAP is present in the scent gland secretions of mustelid species that prey on birds. For these reasons, we chose to test the bird repellency of this material and 3 isomers to European starlings (Stumus vulgaris). Ortho-aminoacetophenone was repellent at concentrations :50.01% in both choice and no-choice feeding tests. The other structural isomers (meta-, para-, alpha-) were less effective. Chemically, the results suggest that hydrogen-bonded ring structure formation and basicity predict …
Nonlethal Bird Repellents: In Search Of A General Model Relating Repellency And Chemical Structure, Larry Clark, Pankaj Shah
Nonlethal Bird Repellents: In Search Of A General Model Relating Repellency And Chemical Structure, Larry Clark, Pankaj Shah
Larry Clark
Identification of potential repellents through molecular modeling has implications for the devel opment of commerciaUy viable, ecologically sound. nonlethal bird repellents. We tested isomers (ortho, meta, para) and moieties (amino, hydroxy, methoxy) of acetophenones for their effectiveness as bird repellents to better understand the nature of repellency in birds. ChemicaUy, basicity of a substituted phenyl ring, as de&ned by the electron-donating substituent, probably is an important feature infiuencing repellency; i.e., more basic substituents result in more potent repellents. Isomeric position of the electron-donating substituent, which leads to resonance of lone pairs of electrons.• is also an important feature of repellency; …
Prediction Of Avian Repellency From Chemical Structure: The Aversiveness Of Vanillin, Vanillyl Alcohol, And Veratryl Alcohol, Pankaj Shah, Larry Clark, Russel Mason
Prediction Of Avian Repellency From Chemical Structure: The Aversiveness Of Vanillin, Vanillyl Alcohol, And Veratryl Alcohol, Pankaj Shah, Larry Clark, Russel Mason
Larry Clark
The effectiveness of bird repellents is associated with the presence of an electron-withdrawing group (carbonyl or carboxyl) and an electron-donating group in resonance on a phenyl ring. The present experiments were designed to examine the relative importance of these structural features. European starlings (Sturnus vulgaris) were presented with vanillin, vanillyl alcohol, and veratryl alcohol in two-cup and one-cup feeding trials and in one-bottle drinking tests. In feeding trials, veratryl alcohol was significantly more aversive than the other two chemicals. In drinking tests. veratryl alcohol was repellent only at the highest concentration (0.5% ml/ml), and was lethal at that concentration and …