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Full-Text Articles in Neuroscience and Neurobiology
Developmental Decline In Neuronal Regeneration By The Progressive Change Of Two Intrinsic Timers, Yan Zou, Hui Chiu, Anna Zinovyeva, Victor Ambros, Chiou-Fen Chuang, Chieh Chang
Developmental Decline In Neuronal Regeneration By The Progressive Change Of Two Intrinsic Timers, Yan Zou, Hui Chiu, Anna Zinovyeva, Victor Ambros, Chiou-Fen Chuang, Chieh Chang
Victor R. Ambros
Like mammalian neurons, Caenorhabditis elegans neurons lose axon regeneration ability as they age, but it is not known why. Here, we report that let-7 contributes to a developmental decline in anterior ventral microtubule (AVM) axon regeneration. In older AVM axons, let-7 inhibits regeneration by down-regulating LIN-41, an important AVM axon regeneration-promoting factor. Whereas let-7 inhibits lin-41 expression in older neurons through the lin-41 3' untranslated region, lin-41 inhibits let-7 expression in younger neurons through Argonaute ALG-1. This reciprocal inhibition ensures that axon regeneration is inhibited only in older neurons. These findings show that a let-7-lin-41 regulatory circuit, which was previously …
Human-Specific Histone Methylation Signatures At Transcription Start Sites In Prefrontal Neurons, Hennady Shulha, Jessica Crisci, Denis Reshetov, Jogender Tushir, Iris Cheung, Rahul Bharadwaj, Hsin-Jung Chou, Isaac Houston, Cyril Peter, Amanda Mitchell, Wei-Dong Yao, Richard Myers, Jiang-Fan Chen, Todd Preuss, Evgeny Rogaev, Jeffrey Jensen, Zhiping Weng, Schahram Akbarian
Human-Specific Histone Methylation Signatures At Transcription Start Sites In Prefrontal Neurons, Hennady Shulha, Jessica Crisci, Denis Reshetov, Jogender Tushir, Iris Cheung, Rahul Bharadwaj, Hsin-Jung Chou, Isaac Houston, Cyril Peter, Amanda Mitchell, Wei-Dong Yao, Richard Myers, Jiang-Fan Chen, Todd Preuss, Evgeny Rogaev, Jeffrey Jensen, Zhiping Weng, Schahram Akbarian
Hsin-Jung Chou
Cognitive abilities and disorders unique to humans are thought to result from adaptively driven changes in brain transcriptomes, but little is known about the role of cis-regulatory changes affecting transcription start sites (TSS). Here, we mapped in human, chimpanzee, and macaque prefrontal cortex the genome-wide distribution of histone H3 trimethylated at lysine 4 (H3K4me3), an epigenetic mark sharply regulated at TSS, and identified 471 sequences with human-specific enrichment or depletion. Among these were 33 loci selectively methylated in neuronal but not non-neuronal chromatin from children and adults, including TSS at DPP10 (2q14.1), CNTN4 and CHL1 (3p26.3), and other neuropsychiatric susceptibility …