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Role Of The Human Cytomegalovirus Ie2 Protein On Transcriptional Regulation Of Viral Promoters, Siabhon Michelle Harris
Role Of The Human Cytomegalovirus Ie2 Protein On Transcriptional Regulation Of Viral Promoters, Siabhon Michelle Harris
Theses and Dissertations in Biomedical Sciences
Human cytomegalovirus (HCMV) is a ubiquitous pathogen able to cause severe mortality and morbidity in immuno-compromised individuals. Successful infection by HCMV is dependent on expression of viral genes essential for replication. Immediate early (IE) gene products are the first subset of viral genes to be expressed during infection and function as key transcriptional regulators. IE2 is one the most predominantly expressed IE proteins and is essential for HCMV infection. IE2 transactivates several viral promoters, including those of the essential viral DNA polymerase (UL54) and UL112-113 gene regions. IE2 is also able to autoregulate is own expression and repress expression of …