Open Access. Powered by Scholars. Published by Universities.®
Washington University in St. Louis
Chikungunya virus, Interferon alpha, Interferon beta, type I interferons
Articles 1 - 1 of 1
Full-Text Articles in Virology
Type I Interferon Regulation Of Chikungunya Virus Pathogenesis, Marissa Christine Locke
Type I Interferon Regulation Of Chikungunya Virus Pathogenesis, Marissa Christine Locke
Arts & Sciences Electronic Theses and Dissertations
Chikungunya virus (CHIKV) is an arthritogenic alphavirus that acutely causes fever as well as severe joint and muscle pain. Chronic musculoskeletal pain persists in a substantial fraction of patients for months to years after the initial infection, yet we still have a poor understanding of the mechanisms responsible for chronic disease. While replicating virus has not been detected in joint-associated tissues of patients with persistent arthritis nor in various animal models at convalescent time points, viral RNA is detected months after acute infection. However, there has been a lack of tools to study the mechanisms of chronic CHIKV disease. To …