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Full-Text Articles in Pathogenic Microbiology
Evolution Of Bordetella Pertussis Genome May Play A Role In The Increased Rate Of Whooping Cough Cases In The United States, Kevin Loftus
Evolution Of Bordetella Pertussis Genome May Play A Role In The Increased Rate Of Whooping Cough Cases In The United States, Kevin Loftus
Senior Honors Projects, 2010-2019
Bordetella pertussis is the bacterium responsible for pertussis, a disease commonly referred to as whooping cough. Recently, pertussis has made a resurgence in the U.S. despite high-vaccination coverage. Possible causes of the increased number of pertussis cases include genetic evolution of B. pertussis, increased awareness of the disease, better laboratory diagnostics, and the switch from a whole-cellular (wP) vaccine to an acellular vaccine (aP) in the 1990s. Fortunately, just as B. pertussis is evolving, so is the arsenal of technologies used to understand and combat this pathogenic bacterium. Whole genome sequencing is one technology that helps researchers better understand …
Antibacterial Properties Of Novel Amphiphiles: Exploring Structure-Activity Relationships, Reafa Hossain
Antibacterial Properties Of Novel Amphiphiles: Exploring Structure-Activity Relationships, Reafa Hossain
Senior Honors Projects, 2010-2019
The increased cases of antibiotic resistance have large implication in hospital settings where infections by antibiotic resistant bacteria are harder to treat resulting in longer stays at the hospital, which drastically increases the costs to patients and hospitals. To address this matter, many research groups are searching for an alternative to antibiotics. One option is the development of amphiphiles, some of which have antibacterial properties. Amphiphiles contain a hydrophilic, polar head group, and a hydrophobic, nonpolar tail, which may intercalate into the cell membrane, resulting in cell lysis. Understanding the impact of amphiphile geometry on antibacterial activity allows for the …