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Full-Text Articles in Pathogenic Microbiology
The Rapid Identification Of Novel Anti-Mycobacterial Drugs And The Transporters Involved In Their Resistance, James Carroll
The Rapid Identification Of Novel Anti-Mycobacterial Drugs And The Transporters Involved In Their Resistance, James Carroll
Theses
Despite the success of anti-mycobacterial drugs over the past 70 years, mycobacterial disease, particularly tuberculosis is still responsible for millions of deaths worldwide. Additionally, the emergence of Multidrug Resistant (MDR-TB) and Extensively Drug Resistant (XDR-TB) Tuberculosis throughout the world has motivated calls by the World Health Organization for novel mycobacterial drugs, vaccines and diagnostic tests. Consequently, this study sought to identify and evaluate the efficacy of a range of anti-mycobacterial compounds against a representative cohort of pathogenic mycobacterial species. The development and employment of the rapid, robust and inexpensive microtitre alamarBlue assay (MABA) facilitated the assessment of a vast array …