Open Access. Powered by Scholars. Published by Universities.®

Pathogenic Microbiology Commons

Open Access. Powered by Scholars. Published by Universities.®

2003

Medical Microbiology

Articles 1 - 1 of 1

Full-Text Articles in Pathogenic Microbiology

Spirochete-Platelet Attachment And Thrombocytopenia In Murine Relapsing Fever Borreliosis, Kishore R. Alugupalli, Alan D. Michelson, Isabelle Joris, Tom G. Schwan, Kairbaan Hodivala-Dilke, Richard O. Hynes, John M. Leong Jul 2003

Spirochete-Platelet Attachment And Thrombocytopenia In Murine Relapsing Fever Borreliosis, Kishore R. Alugupalli, Alan D. Michelson, Isabelle Joris, Tom G. Schwan, Kairbaan Hodivala-Dilke, Richard O. Hynes, John M. Leong

Open Access Articles

Thrombocytopenia is common in persons infected with relapsing fever Borreliae. We previously showed that the relapsing fever spirochete Borrelia hermsii binds to and activates human platelets in vitro and that, after platelet activation, high-level spirochete-platelet attachment is mediated by integrin alpha IIb beta 3, a receptor that requires platelet activation for full function. Here we established that B hermsii infection of the mouse results in severe thrombocytopenia and a functional defect in hemostasis caused by accelerated platelet loss. Disseminated intravascular coagulation, immune thrombocytopenic purpura, or splenic sequestration did not play a discernible role in this model. Instead, spirochete-platelet complexes were ...