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Full-Text Articles in Pathogenic Microbiology
Modulation Of The Nf-Κb Pathway By Bordetella Pertussis Filamentous Hemagglutinin, Tzvia Abramson, Hassya Kedem, David A. Relman
Modulation Of The Nf-Κb Pathway By Bordetella Pertussis Filamentous Hemagglutinin, Tzvia Abramson, Hassya Kedem, David A. Relman
Faculty Publications, Biological Sciences
Background
Filamentous hemagglutinin (FHA) is a cell-associated and secreted adhesin produced by Bordetella pertussis with pro-apoptotic and pro-inflammatory activity in host cells. Given the importance of the NF-κB transcription factor family in these host cell responses, we examined the effect of FHA on NF-κB activation in macrophages and bronchial epithelial cells, both of which are relevant cell types during natural infection.
Methodology/Principal Findings
Exposure to FHA of primary human monocytes and transformed U-937 macrophages, but not BEAS-2B epithelial cells, resulted in early activation of the NF-κB pathway, as manifested by the degradation of cytosolic IκBα, by NF-κB DNA binding, and …