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Full-Text Articles in Pathogenic Microbiology
Metalloregulation Of Helicobacter Pylori Physiology And Pathogenesis, Kathryn P. Haley, Jennifer A. Gaddy
Metalloregulation Of Helicobacter Pylori Physiology And Pathogenesis, Kathryn P. Haley, Jennifer A. Gaddy
Peer Reviewed Articles
Helicobacter pylori is a Gram-negative spiral-shaped bacterium that colonizes over half of the world's population. Chronic H. pylori infection is associated with increased risk for numerous disease outcomes including gastritis, dysplasia, neoplasia, B-cell lymphoma of mucosal-associated lymphoid tissue (MALT lymphoma), and invasive adenocarcinoma. The complex interactions that occur between pathogen and host are dynamic and exquisitely regulated, and the relationship between H. pylori and its human host are no exception. To successfully colonize, and subsequently persist, within the human stomach H. pylori must temporally regulate numerous genes to ensure localization to the gastric lumen and coordinated expression of virulence factors …
Helicobacter Pylori: Genomic Insight Into The Host-Pathogen Interaction, Kathryn P. Haley, Jennifer A. Gaddy
Helicobacter Pylori: Genomic Insight Into The Host-Pathogen Interaction, Kathryn P. Haley, Jennifer A. Gaddy
Peer Reviewed Articles
The advent of genomic analyses has revolutionized the study of human health. Infectious disease research in particular has experienced an explosion of bacterial genomic, transcriptomic, and proteomic data complementing the phenotypic methods employed in traditional bacteriology. Together, these techniques have revealed novel virulence determinants in numerous pathogens and have provided information for potential chemotherapeutics. The bacterial pathogen, Helicobacter pylori, has been recognized as a class 1 carcinogen and contributes to chronic inflammation within the gastric niche. Genomic analyses have uncovered remarkable coevolution between the human host and H. pylori. Perturbation of this coevolution results in dysregulation of the …