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Full-Text Articles in Pathogenic Microbiology
Trypanosome Lytic Factor Mediated Immunity Against Leishmania Sp., Jyoti Pant
Trypanosome Lytic Factor Mediated Immunity Against Leishmania Sp., Jyoti Pant
Dissertations, Theses, and Capstone Projects
Trypanosome Lytic Factor (TLF) is an innate immunity complex that was originally discovered to protect against African Trypanosomes. The major components of TLF are Apolipoprotein A1 (APOA1), Apolipoprotein L1 (APOL1) and HPR (Haptoglobin Related Protein), where APOL1 is necessary and sufficient for trypanolysis. Recently we have shown that TLF ameliorates infections by cutaneous Leishmania species. Here we investigated the effect of different primate and human TLF against different Leishmania sp. Our result shows that TLF kills metacyclic promastigotes of cutaneous Leishmania sp. within immune cells such as neutrophils and macrophages by two different mechanism. Using transiently transfected and germline transgenic …
Group B Streptococcus Induces Neutrophil Recruitment To Gestational Tissues And Elaboration Of Extracellular Traps And Nutritional Immunity, Visheh Kothary, Ryan S. Doster, Lisa M. Rogers, Leslie A. Kirk, Kelli L. Boyd, Joann Romano-Keeler, Kathryn Haley, Shannon D. Manning, David M. Aronoff, Jennifer A. Gaddy
Group B Streptococcus Induces Neutrophil Recruitment To Gestational Tissues And Elaboration Of Extracellular Traps And Nutritional Immunity, Visheh Kothary, Ryan S. Doster, Lisa M. Rogers, Leslie A. Kirk, Kelli L. Boyd, Joann Romano-Keeler, Kathryn Haley, Shannon D. Manning, David M. Aronoff, Jennifer A. Gaddy
Peer Reviewed Articles
Streptococcus agalactiae, or Group B Streptococcus (GBS), is a gram-positive bacterial pathogen associated with infection during pregnancy and is a major cause of morbidity and mortality in neonates. Infection of the extraplacental membranes surrounding the developing fetus, a condition known as chorioamnionitis, is characterized histopathologically by profound infiltration of polymorphonuclear cells (PMNs, neutrophils) and greatly increases the risk for preterm labor, stillbirth, or neonatal GBS infection. The advent of animal models of chorioamnionitis provides a powerful tool to study host-pathogen relationships in vivo and ex vivo. The purpose of this study was to evaluate the innate immune response …