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Full-Text Articles in Pathogenic Microbiology
Quorum Sensing And Other Aspects Of The Biology Of Candida Albicans, Kenneth W. Nickerson
Quorum Sensing And Other Aspects Of The Biology Of Candida Albicans, Kenneth W. Nickerson
Kenneth Nickerson Papers
Most dimorphic fungi exhibit cell density dependent effects in that they grow as yeasts when inoculated at > 106 cells per ml and as mycelia when inoculated at < 106 cells per ml. For Candida albicans, we discovered (2001) that this phenomenon (quorum sensing) is due to the production and secretion of the C15 isoprenoid trans-trans farnesol. Since then, we found that C. albicans cells treated with sublethal levels of zaragozic acid (2003) or fluconazole (2004) produced 10-40X more farnesol and that these fluconazole treated cells were ca. 5X more toxic to mice following tail vein injection. This suggestion …
Quorum Sensing Activity In Ophiostoma Ulmi: Effects Of Fusel Oils And Branched Chain Amino Acids On Yeast-Mycelial Dimorphism, A. Berrocal, J. Navarrete, C. Oviedo, K. W. Nickerson
Quorum Sensing Activity In Ophiostoma Ulmi: Effects Of Fusel Oils And Branched Chain Amino Acids On Yeast-Mycelial Dimorphism, A. Berrocal, J. Navarrete, C. Oviedo, K. W. Nickerson
Kenneth Nickerson Papers
Aims: For Ophiostoma (Ceratocystis) ulmi, the ability to undergo morphological change is a crucial factor for its virulence. To gain an understanding of quorum- sensing activity in O. ulmi as it relates to yeast-mycelium dimorphism control, this study examines the effects of branched-chain amino acids as well as their fusel alcohols and fusel acids as quorum sensing molecules.
Methods and Results: In a defined medium containing glucose, proline and salts, O. ulmi grew as yeasts when the culture was inoculated with a high density of spores (2-107 CFU ml-1) and as mycelia when inoculated …