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Full-Text Articles in Pathogenic Microbiology
A High-Fat/High-Protein, Atkins-Type Diet Exacerbates Clostridioides (Clostridium) Difficile Infection In Mice, Whereas A High-Carbohydrate Diet Protects, Chrisabelle C. Mefferd, Shrikant S. Bhute, Jacqueline R. Phan, Jacob V. Villarama, Dung M. Do, Stephanie Alarcia, Ernesto Abel-Santos, Brian P. Hedlund
A High-Fat/High-Protein, Atkins-Type Diet Exacerbates Clostridioides (Clostridium) Difficile Infection In Mice, Whereas A High-Carbohydrate Diet Protects, Chrisabelle C. Mefferd, Shrikant S. Bhute, Jacqueline R. Phan, Jacob V. Villarama, Dung M. Do, Stephanie Alarcia, Ernesto Abel-Santos, Brian P. Hedlund
Chemistry and Biochemistry Faculty Research
Clostridioides difficile (formerly Clostridium difficile) infection (CDI) can result from the disruption of the resident gut microbiota. Western diets and popular weight-loss diets drive large changes in the gut microbiome; however, the literature is conflicted with regard to the effect of diet on CDI. Using the hypervirulent strain C. difficile R20291 (RT027) in a mouse model of antibiotic-induced CDI, we assessed disease outcome and microbial community dynamics in mice fed two high-fat diets in comparison with a high-carbohydrate diet and a standard rodent diet. The two high-fat diets exacerbated CDI, with a high-fat/high-protein, Atkins-like diet leading to severe CDI and …