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Full-Text Articles in Microbiology
Cd28 Costimulation Requirement For Interferon-Y Secretion By Natural Killer T Cells During Hepatitis B Virus Infection, Paul J. Renick
Cd28 Costimulation Requirement For Interferon-Y Secretion By Natural Killer T Cells During Hepatitis B Virus Infection, Paul J. Renick
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Natural Killer T cells (NKT cells) are a unique subset of lymphocytes that express natural killer (NK) and T cell receptors (TCR). The NKT cell population includes four separate subclasses. This paper will focus on Category I NKT cells which possess a canonical TCR receptor (Va14Ja281) that recognizes only hydrophobic antigens presented by CD1d molecules. These cells are believed to play an important regulatory role in immunity. A variety of disease conditions, including cancer, infections and Type I diabetes, are controlled by NKT cells. NKT cells are also capable of secreting large quantities of cytokines, namely interleukin-4 (IL-4) and interferon-gamma …