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Full-Text Articles in Microbiology
Hybrid Recombineering: Crispr/Cas9 Mutagenesis Of Murine Cytomegalovirus Bac, Cody Sain
Hybrid Recombineering: Crispr/Cas9 Mutagenesis Of Murine Cytomegalovirus Bac, Cody Sain
Haslam Scholars Projects
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that can asymptomatically infect immunocompetent hosts with little-to-no impact. Conversely, HCMV can trigger life-threatening disease in immunocompromised hosts such as neonates, organ transplant recipients, and people living with AIDS. HCMV is a unique pathogen in that it can hijack the immune system for its benefit and disseminates throughout the body using host immune cells. Previous studies suggest that innate immune cells are responsible for viral dissemination. However, adequate methods for investigating the spread of CMV within a murine model remain incomplete. We implicate the innate immune cell the neutrophil as a major cell …