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Is The Ubiquitous Antibacterial Agent Triclosan An Uncoupler Of Mammalian Mitochondria, Hina Hashmi
Is The Ubiquitous Antibacterial Agent Triclosan An Uncoupler Of Mammalian Mitochondria, Hina Hashmi
Honors College
Triclosan (TCS), an antibacterial agent widely found in household and clinical products, is readily absorbed into human skin, but TCS effects on mammalian cells are largely unknown. TCS has been found to alleviate symptoms of human eczema, via an unknown mechanism. Mast cells are ubiquitous, key players in allergy, infectious disease, carcinogenesis, autism, and many other diseases and physiological functions. One important function of mast cells is release of pro-inflammatory mediators from intracellular granules (degranulation) upon challenge with antigen. Non-cytotoxic doses of TCS inhibit several functions of both human (HMC-1.2) and rat (RBL-2H3) mast cells, including degranulation. Previous work in …